Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
La asesoría del psicopedagogo y la dirección del círculo infantil Psychological counseling and nursery school management [PDF]
Transformación, 2017 The paper refers the impact of psychological counseling on improving nursery school management. By studying the actual practices of these professionals and institutions, constructing a theoretical framework, and exchanging with specialists, the authors ...
Laritza Raquel del Risco López +2 more
doaj
Self-Management Education [PDF]
Canadian Journal of Diabetes, 2013 Helen, Jones +4 more
openaire +2 more sources
Strategy of Financing Management to Improve the Quality of Islamic Education Institution
, 2022 Riinawati Riinawati
openalex +2 more sources
Business Typology for Examining the Risk Management Strategy in Relation to the Activities of Higher Education Institutions in the Sultanate of Oman [PDF]
, 2020 Ibrahim Rashid Al Shamsi
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Research on Supportive Psychosocial, Drug Treatment, and Health Education Intervention and Health Management Model of Community-Residing Elderly Adults With Late Life Depression in Liaoning Province: A Protocol [PDF]
, 2020 Li Duan +4 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Follow up of a gestational trophoblastic disease management: Need for information education and communication (IEC) module [PDF]
, 2023 Namika Dwivedi, Choudhary Harsha
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source