Results 81 to 90 of about 3,159,903 (327)
Systems management techniques and problems [PDF]
, 1971 Report is reviewed which discusses history and trends of systems management, its basic principles, and nature of problems that lend themselves to systems approach.
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Boundary Objects and their Use in Agile Systems Engineering
, 2019 Agile methods are increasingly introduced in automotive companies in the attempt to become more efficient and flexible in the system development. The adoption of agile practices influences communication between stakeholders, but also makes companies ...
Knauss, Eric +3 more
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Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Applying COCOMO II for a DO-178C Safety-Critical Software Effort Estimation
Journal of Aerospace Technology and Management, 2019 This paper provides a real example of applying COCOMO II as an estimation technique for the required software development effort in a safety-critical software application project following the DO-178C processes. The main goal and contribution of the case
Lucas Pereira dos Santos +1 more
doaj +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Engineering, Project, and Production Management: Lessons [PDF]
Journal of Engineering, Project, and Production Management, 2013 This Journal always faces the challenge of bringing together the three disciplines in a common pool of management research. This edition provides at least a paper in each of the disciplines.
Kassim Gidado
doaj
Strategies for COVID-19 Pandemic Recovery. Applying Engineering Asset Management Principles [PDF]
, 2020 Versión preprint permitida por el editor Elsevier para subir a repositorios: http://sherpa.ac.uk/romeo/issn/2468-2667/es/Current COVID-19 pandemic available data for Spain, Andalusia an its eight provinces have been analyzed.
Crespo Márquez, Adolfo +1 more
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Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
BuildingsEngineering construction involves many internal factors and external environmental factors, resulting in conflict or uncoordinated problems in engineering management.
Weiwei Zuo, Ning Yan, Qiankun Wang
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Special issue: Advances in Engineering Networks
International Journal of Production Management and Engineering, 2019 This special issue of the International Journal of Production Management and Engineering is dedicated on the most recent and relevant research, theories and practices in Industrial Engineering and Operations Management presented at the 12th International
R. de Castro +6 more
doaj +1 more source