Results 111 to 120 of about 6,565,603 (355)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Managing Science

, 2011
Quality Assessment. Rector manificus , ladies and gentlemen, the answer that is given increasingly within the science system reads, “Let us count.” Let us count how many Euros have been acquired, how many publications are realized, and how many citations are generated. The higher the score, the better the researcher. However, it is not that simple.
openaire   +3 more sources

Two notes on the joint replenishment problem under constant demand [PDF]

Inventory Control;Inventory Models;management ...
Eijs, M.J.G. van
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Science-Based Management of America's Ocean Fish: A Growing Success Story [PDF]

, 2011
The United States is on the verge of completing a new science-based management system for ocean fish that will ensure sustainable fisheries. Congress should support managers as they achieve this goal, which will deliver an enduring legacy of healthy fish

core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Spatiotemporal patterns and drivers of ecosystem service interactions in karst regions: Insights for environmental protection and sustainability

iScience
Summary: Comprehending the interrelationships among ecosystem services (ESs) across temporal and spatial scales is fundamental for effective ES management.
Xuemao Zhang, Binggeng Xie, Junhan Li, Chuan Yuan, Kaichun Zhou, Jing Xie, Xiaofei Pang   +6 more
doaj   +1 more source

Publishing Environmental Assessment and Management Science: Crossing the Hurdles. [PDF]

Bioscience, 2020
Efroymson RA, Peterson MJ.
europepmc   +1 more source

Efficiency of selective information dissemination within the system of information and communication support of university science (a case study of the Scientific Library of Novosibirsk State University of Economics and Management)

, 2020
Tatyana Komleva
openalex   +2 more sources

Forest Measurements [PDF]

, 2019
Forest measurements, one of the cornerstones in the foundation of forestry, is the art and science of providing the quantitative information about trees and forest stands necessary for forest management, planning, and research. The updated edition (sixth
Weng, Yuhi
core   +1 more source