A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Biomaterials science and surface engineering strategies for dental peri-implantitis management [PDF]
Ya-Meng Yu +5 more
openalex +1 more source
Total quality management (tqm) and systems thinking in translational science [PDF]
, 2018 R. E. F. Smith
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Modeling Scientists as Agents. How Scientists Cope with the Challenges of the New Public Management of Science [PDF]
The paper at hand applies agent-based modeling and simulations (ABMS) as a tool to reconstruct and to analyze how the science system works. A Luhmannian systems perspective is combined with a model of decision making of individual actors.
Johannes Weyer +2 more
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Science and Politics in China’s Official Water System: the Management of the Qiantang River (1927-1949) [PDF]
, 2020 LI Hai-jing, Sally K. Church
openalex +1 more source
A review of the Management Science theory and its application in contemporary businesses [PDF]
, 2021 Japhet Osazefua Imhanzenobe
openalex +1 more source
Brazilian Journal of Information Science, 2013 The knowledge management (KM) has become an important guideline for the Information and Knowledge Society, as well as for libraries. Thus, this article presents a literature review using a systematic approach, with the proposition of identifying trends ...
Roberta Moraes de Bem +1 more
doaj
POLICY IMPLICATIONS ON THE REDUCTION OF NITROGEN FERTILIZER USE ON NON-IRRIGATED CORN-WINTER WHEAT PRODUCTION IN NORTH ALABAMA [PDF]
Environmental and economic effects of nitrogen fertilizer reduction on North Alabama small farms are evaluated using GPFARM. GPFARM incorporates climate, soil data and management practices to simulate science and economic analysis for a farm/ranch ...
Befecadu, Joseph +2 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source