Results 111 to 120 of about 26,401,493 (299)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Building blocks for enhancing personnel performance: activities, best practices and lessons learned from Ethiopia

open access: yesJournal of Pharmaceutical Policy and Practice, 2014
Daniel Taddesse   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Integrity management systems

open access: yes
Recent years have seen various attempts at conceptualising integrity management within organisations. This chapter focuses on those integrity management models that take a systems approach. This emphasises interconnectedness and requisite variety, as well as the processual and iterative nature of integrity management and the importance of grassroots ...
Maesschalck, Jeroen   +2 more
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Analysis of work status quo its of specialist nurses and influencing factors in Jiangxi province

open access: yesHuli yanjiu, 2018
To inquire into the work status and influencing factors of specialized nurses in Jiangxi province.Methods:A total of 361 specialist nurses who had obtained the certificate from 11 specialities were investigated with self-designed questionnaire in Jiangxi.
陈娇   +4 more
doaj  

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