Results 111 to 120 of about 600,125 (293)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Quantitative Spectroscopy of Supernovae for Dark Energy Studies
, 2005 Detailed quantitative spectroscopy of Type Ia supernovae (SNe~Ia) provides crucial information needed to minimize systematic effects in both ongoing SNe Ia observational programs such as the Nearby Supernova Factory, ESSENCE, and the SuperNova Legacy ...
Baron, E. +8 more
core +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Regulation of withdrawals in individual account systems [PDF]
Funded mandatory pension systems based on individual accounts are spreading around the world. With the maturation of those systems, regulating the withdrawal of retirement savings will become increasingly important.
Walliser, Jan
core
Robust, Recognizable and Legitimate: Strengthening India's Appliance Efficiency Standards and Labels Through Greater Civil Society Involvement [PDF]
, 2013 Residential use accounts for 14 percent of global energy consumption. Appliance standards alone could achieve 17 percent energy reductions in the residential sector.
Bharath Jairaj +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Considerations for mandatory childhood immunization programs
Canada Communicable Disease Report, 2020 Noni E MacDonald +2 more
openaire +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
SHOULD IMPORTS FREE-RIDE OR HELP PAY-- DECISIONS ABOUT GENERIC PROMOTION PROGRAMS FOR AGRICULTURAL COMMODITIES [PDF]
Many U.S. agricultural commodity industries are currently considering if and how they might implement a mandatory national generic promotion program. As U.S.
Ricks, Donald J., Sterns, James A.
core +1 more source