Advances in the neurotoxicity of ecological pesticide maneb: mechanisms and implications for human health [PDF]
Frontiers in Public HealthManeb, a typical dithiocarbamate pesticide, is widely used in the control of agricultural fungi in lands. Its residues with main metabolites in environmental media pose risks to environmental safety and human health. This research summarized the research
Yuping Xi +9 more
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Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation [PDF]
Journal of Neuroinflammation, 2023 Introduction The mechanisms of cognitive impairments in Parkinson’s disease (PD) remain unknown. Accumulating evidence revealed that brain neuroinflammatory response mediated by microglial cells contributes to cognitive deficits in neuropathological ...
Liyan Hou +8 more
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Thiol-reactivity of the fungicide maneb
Redox Biology, 2014 Maneb (MB) is a manganese-containing ethylene bis-dithiocarbamate fungicide that is implicated as an environmental risk factor for Parkinson's disease, especially in combination with paraquat (PQ).
James R. Roede, Dean P. Jones
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Genetic basis of maneb-induced dopaminergic neurodegeneration in Drosophila. [PDF]
G3 (Bethesda)ABSTRACT Parkinson’s disease (PD) is a complex neurodegenerative disease driven by combined genetic and environmental factors. Human studies support increased PD risk following exposure to the pesticide maneb yet animal studies generally report subtle or no dopaminergic phenotypes unless maneb is combined with ...
Villalobos-Cantor S +2 more
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Resistance of Ascochyta rabiei isolates from chickpeas (Cicer arietinum L.) to fungicides [PDF]
HeliyonAscochyta blight is a disease that causes significant yield losses in chickpea crops in Turkey under favorable environmental conditions. The fungal pathogen Ascochyta rabiei is the causative agent of this disease.
Ali Endes +4 more
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Environment International, 2023 Maneb, a widely-used dithiocarbamate fungicide, remains in the environment and exerts adverse health effects. Epidemiological evidence shows that maneb exposure is associated with a higher risk of Parkinson’s disease (PD), one of the most common ...
Chaoyang Liu +12 more
doaj +1 more source
Smart city of the 22 century: a closing circle
Проект Байкал, 2021 Communications of people or devices eliminate the basic principles of vertical control. New technological breakthroughs based on the energy Internet will change the way people interact with each other and the environment.
Злата Гаевская +1 more
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Characterisation of Neurospheres-Derived Cells from Human Olfactory Epithelium
Cells, 2021 A major problem in psychiatric research is a deficit of relevant cell material of neuronal origin, especially in large quantities from living individuals.
Elena A. Zelenova +9 more
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Journal of Neuroinflammation, 2020 Background The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson’s disease (PD). However, the mechanisms remain unclear.
Liyan Hou +5 more
doaj +1 more source
Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. [PDF]
PLoS ONE, 2012 SNCA and MAPT genes and environmental factors are important risk factors of Parkinson's disease [PD], the second-most common neurodegenerative disease. The agrichemicals maneb and paraquat selectively target dopaminergic neurons, leading to parkinsonism,
Jonathan Wills +6 more
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