Results 191 to 200 of about 66,270 (266)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Effects of a Pringle maneuver on jejunal mucosal oxygenation and blood flow in a porcine model. [PDF]

Sci Rep
Sartori S, Pajk W, Kleinsasser A, Ulmer H, Modler P, Poidinger B, Kotzinger O, Knotzer H, Hasibeder W.   +8 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Female hypospadias by biplanar transrectal ultrasound: a case description. [PDF]

Quant Imaging Med Surg
Yue ZC, Meng J, Ma B, Liu X, Niu K, Wang W, Li TG.   +6 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Efficacy and safety of lung-protective ventilation in neurosurgery: a systematic review and meta-analysis of randomized controlled clinical trials. [PDF]

Front Med (Lausanne)
Liu Y, Cao Q, Pang QY, Liu H.
europepmc   +1 more source

Crossing life-saving thresholds: learning-forgetting trajectories in secondary-school basic life-support training: project threshold-beat. [PDF]

Front Public Health
Cantón-Cortés R, Fernández-Florido P, Fernández-Carbonell A, Parrilla-Ruiz FM, Gómez-Moreno G, Hernández-París MLÁ, Pérez-Villares JM, Cárdenas-Cruz A.   +7 more
europepmc   +1 more source

Calibrated abdominal compression to assess fluid responsiveness in extremely and very preterm neonates: a pilot study. [PDF]

Front Pediatr
Gotchac J, Jammet N, Gérard R, Brousse D, Egger J, Le Cabec E, Renard C, Tandonnet O, Amedro P, Cramaregeas S.   +9 more
europepmc   +1 more source

Standardized Patient vs Video Demonstration for Teaching Psychomotor Skills in Spinal Injury Management to Undergraduate Medical Students: Prospective Interventional Comparative Study. [PDF]

JMIR Form Res
Gayan M, Shrivastava S, Sonowal K, Gogoi A, Goswami H, Pathak P, Kumar B.   +6 more
europepmc   +1 more source

Error in Byline.

JAMA Cardiol
europepmc   +1 more source