Results 51 to 60 of about 238,379 (310)
Stop wasting protein—Proteasome inhibition to target diseases linked to mitochondrial import
EMBO Molecular Medicine, 2019 Mitochondrial dysfunction is linked to various human diseases. Symptoms can occur early in life or manifest progressively during life and include poor muscle coordination or weakness, neurological or developmental problems, or immunodeficiency ...
Markus Habich, Jan Riemer
doaj +1 more source
LENR as a manifestation of weak nuclear interactions. New approach to creating LENR reactors
Radioelectronics. Nanosystems. Information Technologies., 2021 Hypothesis is suggested about the generation of neutrino-antineutrino pairs in collisions of particles of matter at temperatures of several thousand degrees. Particularly intense generation should occur in metals and dense plasma. Resulting neutrinos and antineutrinos can excite exothermic nuclear reactions in the surrounding matter.
Alexander G. Parkhomov +1 more
openaire +1 more source
Clinical Insights Into Hypercalcemia of Malignancy in Childhood
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley +1 more source
Asymptomatic hyper-creatine-kinase-emia as sole manifestation of inclusion body myositis
Neurology International, 2013 Sporadic inclusion body myositis (sIBM) usually manifests with painless weakness of the hand, finger and hip flexors. Absence of symptoms or signs, but mild hyper-CK-emia as the sole manifestation of IBM, has not been reported. We report the case of a 73-
Josef Finsterer +2 more
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Multiple ossified intracranial and spinal meningiomas: a rare case report and literature review
Frontiers in Neurology, 2023 Ossified intracranial meningiomas (OIM) and ossified spinal meningiomas (OSM) are rare neoplasms of mesenchymal origin that predominantly manifest in the spinal cord and infrequently in the cranial region, accounting for ~0. 7–5.5% of all meningiomas. It
Jian Wang +8 more
doaj +1 more source
Tocqueville, Pascal, and the Transcendent Horizon [PDF]
, 2007 Most students of Tocqueville know of his remark, “There are three men with whom I live a little every day; they are Pascal, Montesquieu, and Rousseau.” In this paper I trace out the contours of Pascal’s influence upon Tocqueville’s understanding of the ...
Jech, Alexander
core
Weak interactions as manifestations of the substructure of leptons and quarks
Physics Letters B, 1981 A new model for the substructure of leptons, quarks and weak bosons is investigated. The weak interactions are residual effects due to the substructure. No spontaneous symmetry breaking is needed to generate masses. The structure of the weak interactions at high energies is expected to deviate substantially from the one predicted by the standard SU(2) ×
H. Fritzsch, G. Mandelbaum
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Evaluation and management of polymyositis
Indian Journal of Dermatology, 2012 Polymyositis (PM) is one of the inflammatory myopathies, disorders characterized pathologically by the presence of inflammatory infiltrates in striated muscle. The principal clinical manifestation of PM is proximal muscle weakness.
Kathy Hunter, Michael G Lyon
doaj +1 more source