Results 71 to 80 of about 730,787 (266)

A Comparative Study of the Transmission from Plurality to Oneness in Plato and MullaSadra's Ontology [PDF]

open access: yesحکمت معاصر, 2014
Plato on the basis of his unifier viewpoint offered the theory of Idea and other cosmological related to creation and the chain and arrangement of beings. He also placed the principal of Goodness in the climax of the pyramid of his ontology, and by which
Zahra Mohammadi Mohammadieh   +1 more
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Regional Patch-Based Feature Interpolation Method for Effective Regularization

open access: yesIEEE Access, 2020
Deep Convolutional Neural Networks (CNNs) can be overly dependent on training data, causing a generalization problem in which trained models may not predict real-world datasets.
Soojin Jang   +3 more
doaj   +1 more source

Dirac manifolds [PDF]

open access: yesTransactions of the American Mathematical Society, 1990
A Dirac structure on a vector space V V is a subspace of V V with a skew form on it. It is shown that these structures correspond to subspaces of V ⊕ V ∗ V \oplus {V^{\ast }} satisfying a maximality ...
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Fuchsian Manifolds [PDF]

open access: yesTransactions of the American Mathematical Society, 1975
Recently Eberlein and O’Neill have investigated Riemannian manifolds of negative sectional curvature. For visibility manifolds, they have obtained a classification into three types: parabolic, axial and fuchsian. Fundamental groups of fuchsian manifolds of finite type will be investigated.
openaire   +2 more sources

MANIFOLD MATCHING COMPLEXES

open access: yesMathematika, 2020
43 pages, 32 figures Version 2 added a reference. Version 2 extends the theorems by weakening the hypotheses from combinatorial to homology manifolds, but shows the manifolds that occur are all ...
Bayer, Margaret   +2 more
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

DIMSUB, a computer program for designing microirrigation subunits. Tool definition and case studies

open access: yesScientia Agricola
: DIMSUB is a computer program to complement a decision support tool (DST) to effectively study different hydraulic design alternatives in microirrigation systems. We developed environments in Visual Basic for applications for Microsoft Excel® that allow
Carmen Virginia Palau   +3 more
doaj   +1 more source

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