Results 41 to 50 of about 18,794 (253)
STAR ProtocolsSummary: Here, we present a protocol for using Brain and Organoid Manifold Alignment (BOMA), a cloud-based web app for comparative gene expression data analysis between brains and organoids.
Xiang Huang +4 more
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Unsupervised Domain Adaptation by Mapped Correlation Alignment
IEEE Access, 2018 The goal of unsupervised domain adaptation aims to utilize labeled data from source domain to annotate the target-domain data, which has none of the labels.
Yun Zhang +3 more
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Nonlinear Feature Extraction Through Manifold Learning in an Electronic Tongue Classification Task
Sensors, 2020 A nonlinear feature extraction-based approach using manifold learning algorithms is developed in order to improve the classification accuracy in an electronic tongue sensor array.
Jersson X. Leon-Medina +3 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Manifold-Aligned Generative Transport
CoRR64 pages, 5 ...
Xinyu Tian, Xiaotong Shen
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Manifold alignment using Procrustes analysis
Proceedings of the 25th international conference on Machine learning - ICML '08, 2008 In this paper we introduce a novel approach to manifold alignment, based on Procrustes analysis. Our approach differs from "semi-supervised alignment" in that it results in a mapping that is defined everywhere - when used with a suitable dimensionality reduction method - rather than just on the training data points.
Wang, Chang, Mahadevan, Sridhar
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Alignment of vector fields on manifolds via contraction mappings
Учёные записки Казанского университета: Серия Физико-математические науки, 2018 According to the manifold hypothesis, high-dimensional data can be viewed and meaningfully represented as a lower-dimensional manifold embedded in a higher dimensional feature space. Manifold learning is a part of machine learning where an intrinsic data
O.N. Kachan +2 more
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