Results 41 to 50 of about 30,962 (265)

Hypersurfaces in statistical manifolds

open access: yesDifferential Geometry and its Applications, 2009
A statistical structure on a manifold \(M\) consists of a Riemannian metric \(g\) and a torsion-free affine connection \(\nabla\) that satisfies \( (\nabla_Xg)(Y,Z) = (\nabla_Yg)(X,Z)\) for all vector fields \(X\), \(Y\), and \(Z\) on \(M\). The statistical manifold \((M, \nabla, g)\) has constant curvature \(k\) if \[ R^\nabla(X,Y)Z = k(g(Y,Z)X-g(X,Z ...
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

PCA-Based Matrix CFAR Detection for Radar Target

open access: yesEntropy, 2020
In radar target detection, constant false alarm rate (CFAR), which stands for the adaptive threshold adjustment with variation of clutter to maintain the constant probability of false alarm during the detection, plays an important role.
Zheng Yang, Yongqiang Cheng, Hao Wu
doaj   +1 more source

SYMPLECTIC STRUCTURES ON STATISTICAL MANIFOLDS [PDF]

open access: yesJournal of the Australian Mathematical Society, 2011
AbstractA relationship between symplectic geometry and information geometry is studied. The square of a dually flat space admits a natural symplectic structure that is the pullback of the canonical symplectic structure on the cotangent bundle of the dually flat space via the canonical divergence. With respect to the symplectic structure, there exists a
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Computing Bi-Invariant Pseudo-Metrics on Lie Groups for Consistent Statistics

open access: yesEntropy, 2015
In computational anatomy, organ’s shapes are often modeled as deformations of a reference shape, i.e., as elements of a Lie group. To analyze the variability of the human anatomy in this framework, we need to perform statistics on Lie groups. A Lie group
Nina Miolane, Xavier Pennec
doaj   +1 more source

Topological terms of (2+1)d flag-manifold sigma models

open access: yesJournal of High Energy Physics, 2021
We examine topological terms of (2 + 1)d sigma models and their consequences in the light of classifications of invertible quantum field theories utilizing bordism groups.
Ryohei Kobayashi   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Sordid genealogies: a conjectural history of Cambridge Analytica’s eugenic roots

open access: yesHumanities & Social Sciences Communications, 2020
“Sordid Genealogies: A Conjectural History of Cambridge Analytica’s Eugenic Roots” explores the history of the methods employed by Cambridge Analytica to influence the 2016 US presidential election.
Michael Wintroub
doaj   +1 more source

Kernel Manifold Alignment for Domain Adaptation. [PDF]

open access: yesPLoS ONE, 2016
The wealth of sensory data coming from different modalities has opened numerous opportunities for data analysis. The data are of increasing volume, complexity and dimensionality, thus calling for new methodological innovations towards multimodal data ...
Devis Tuia, Gustau Camps-Valls
doaj   +1 more source

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