Results 71 to 80 of about 30,962 (265)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies. [PDF]

PLoS ONE, 2013
To tackle the heterogeneity of Parkinson's disease symptoms, most functional imaging studies tend to select a uniform group of subjects. We hypothesize that more profound considerations are needed to account for intra/inter-subject clinical variability ...
Štefan Holiga, Karsten Mueller, Harald E Möller, Tomáš Sieger, Matthias L Schroeter, Josef Vymazal, Evžen Růžička, Robert Jech   +7 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Asymmetric Topologies on Statistical Manifolds [PDF]

, 2015
8 pages, in Proceedings of the Second International Conference, GSI 2015, Palaiseau, France, October 28-30 ...
openaire   +4 more sources

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Generative learning for forecasting the dynamics of high-dimensional complex systems

Nature Communications
We introduce generative models for accelerating simulations of high-dimensional systems through learning and evolving their effective dynamics. In the proposed Generative Learning of Effective Dynamics (G-LED), instances of high dimensional data are down
Han Gao, Sebastian Kaltenbach, Petros Koumoutsakos   +2 more
doaj   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Unsupervised Domain Adaptation by Mapped Correlation Alignment

IEEE Access, 2018
The goal of unsupervised domain adaptation aims to utilize labeled data from source domain to annotate the target-domain data, which has none of the labels.
Yun Zhang, Nianbin Wang, Shaobin Cai, Lei Song   +3 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Application of dynamic multi-manifold projections algorithmin statistical process monitoring

Journal of Hebei University of Science and Technology, 2022
To solve the problem of serial correlation of industrial data and the changes of global and local structure of data in some abnormal states,the [BF]"[BFQ]time lag migration" method was used to incorporate dynamic behavior into the multi-manifold ...
Jinyu GUO, Xia WANG
doaj