Results 31 to 40 of about 173,926 (294)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Mannheim - Ludwigshafen [PDF]

Geographica Helvetica
No abstract available.
G. Ammann
doaj   +1 more source

Investigation into the Current State of Nuclear Energy and Nuclear Waste Management—A State-of-the-Art Review

Energies, 2022
Nuclear power can replace fossil fuels and will have a decisive impact on the change in the approach to conventional energy. However, nuclear (or radioactive) wastes are produced by the operation of the nuclear reactors should be safely and properly ...
Mohamed Alwaeli, Viktoria Mannheim
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

EDUCAÇÃO FÍSICA, ESPORTE E LAZER À LUZ DA SOCIOLOGIA DO CONHECIMENTO DE MANNHEIM

Conexões, 2007
O presente texto apresenta a Sociologia do Conhecimento de Mannheim como um possível referencial teórico para se compreender o processo histórico da pluralidade de interpretações dos conceitos de Educação, Educação Física, Esporte e Lazer ...
Dagmar Hunger
doaj   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Referate

Meteorologische Zeitschrift, 1994
Lortz, Dietrich: Hydrodynamik. - BI-Hochschultaschenbuch, Bd. 696, Wissenschaftsverlag Mannheim-Leipzig-Wien-Zürich, 1993; Röth, E.-P.: Ozonloch - Ozonsmog: Grundlagen der Ozonchemie. Meyers Forum 26. - B.I. Taschenbuchverlag, Mannheim, 1994.
Hans Pichler, Stefan Emeis
doaj   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

A crítica da epistemologia na sociologia do conhecimento de Karl Mannheim

Sociedade e Estado, 2011
O artigo analisa a crítica da epistemologia normativa na obra de Karl Mannheim, sublinhando a sua presença tanto na fase mais filosófica, associada ao elogio do historicismo, como na Sociologia do Conhecimento posterior.
Luís de Gusmão
doaj   +1 more source