Results 41 to 50 of about 61,569 (245)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Characterizations of Special Curves [PDF]

open access: yes, 2012
In this study, the new characterizations of special curves are investigated without using the curvatures of these special curves: general helices, slant helices, Bertrand curves, Mannheim curves.
Saracoglu, Semra, Yayli, Yusuf
core  

Local and global gravity

open access: yes, 1996
Our long experience with Newtonian potentials has inured us to the view that gravity only produces local effects. In this paper we challenge this quite deeply ingrained notion and explicitly identify some intrinsically global gravitational effects.
A. W. Overhauser   +18 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

On a New Type Mannheim Curve

open access: yes, 2021
In this paper, we de ne a new type curve as V-Mannheim curve, V Mannheim partner curve and generating curve of Mannheim curve. We give characterization of these curve. In addition, we study a relation between Mannheim curve and spherical curve. Eventually, with Salkowski method, we give an example of the Mannheim curve.
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Smarandache Curves According to Sabban Frame Belonging to Mannheim Curves Pair

open access: yesCommunications Faculty Of Science University of Ankara Series A1Mathematics and Statistics, 2018
Summary: In this paper, we investigate special Smarandache curves according to Sabban frame, using the idea of Mannheim partner curve of spherical indicatrix. We created Sabban frame by means of Mannheim partner curve of spherical indicatrix. We explained that position vectors of a Smarandache curves are consisted by Sabban frame given above.
Şenyurt, Süleyman   +2 more
openaire   +4 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Smarandache curves according to Sabban frame for Darboux vector of Mannheim partner curve [PDF]

open access: yesAIP Conference Proceedings, 2017
In this paper, we investigated special Smarandache curves belonging to Sabban frame drawn on the surface of the sphere by Darboux vector of Mannheim partner curve. We created Sabban frame belonging to this curve. It was explained Smarandache curves position vector is consisted by Sabban vectors belonging to this curve.
Senyurt, Suleyman   +2 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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