Results 191 to 200 of about 208,897 (295)

Outcomes of 87 small‐breed dogs surgically treated for Chiari‐like malformation and syringomyelia

Veterinary Surgery, EarlyView.
Abstract Objective To report the outcomes of titanium mesh (TM) cranioplasty without polymethylmethacrylate (PMMA), incorporating a deliberate gap between the foramen magnum decompression (FMD) surface and the TM, in small‐breed dogs with Chiari‐like malformation and syringomyelia (CM/SM). Study design Retrospective clinical study.
Sung Su Park, Ji Young Park, Ho Jae Han
wiley   +1 more source

New Kinetic Investigations to Better Understand the Mechanism of Polymorphic Transformations of Pharmaceutical Materials Induced by Milling. [PDF]

Pharmaceutics
Guerain M, Dupont A, Danède F, Barkhatova D, Willart JF.   +4 more
europepmc   +1 more source

Optimising exercise intensity for gut health: Effect on microbiota composition, barrier integrity and inflammation in male Wistar rats

Experimental Physiology, EarlyView.
Abstract Exercise influences gut microbiota composition and intestinal permeability, but the optimal intensity for maintaining gut health remains unclear. This study investigates the effects of different exercise intensities on abundance of some gut microbiota, epithelial barrier integrity and inflammatory markers.
Nova Sylviana, Putri Karisa, Nur Faizah Romadona, Imam Megantara   +3 more
wiley   +1 more source

Preparation, characterization and in vitro evaluation of atorvastatin nanosuspensions. [PDF]

PLoS One
Akour YA, Aljaberi A, Hamed SH, Altaher A, Migdadi EM.   +4 more
europepmc   +1 more source

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Experimental Physiology, EarlyView.
Abstract Hepatic ischaemia–reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR‐induced liver damage, mitochondria‐targeted treatment is of the utmost significance for improving outcomes.
Jie Lin, Lei Han, Zhigang Ma, Bo Yuan, Yabin Yu   +4 more
wiley   +1 more source

An Application for Through-Vial Impedance Spectroscopy (TVIS) in the Qualification of the Pirani-Gauge Assessment of the Ice Sublimation Endpoint. [PDF]

Pharmaceutics
Wijesekara PS, Malik K, Matejtschuk P, Smith G.   +3 more
europepmc   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

New polymorph of tofacitinib citrate and in vitro equivalence study of its sustained-release tablets. [PDF]

PLoS One
Wang Y, Wen S, Zhao Y, Gui L, Mou Y, Wang D.   +5 more
europepmc   +1 more source

Narrative review of strategies for blood product shelf‐life extension

Transfusion, EarlyView.
Mike Akaraphanth, Jessica Oudakker, Matthew Paulson, Michael Adam Meledeo, Kristin M. Reddoch‐Cardenas, Lusha Xiang, Steven G. Schauer, Todd Getz   +7 more
wiley   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source