Results 61 to 70 of about 152,345 (256)
BMC Genomics, 2019 Background Alginate is an important cell wall component and mannitol is a soluble storage carbon substance in the brown seaweed Saccharina japonica. Their contents vary with kelp developmental periods and harvesting time. Alginate and mannitol regulatory
Zhanru Shao +6 more
doaj +1 more source
Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations
Advanced Science, EarlyView.Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford +3 more
wiley +1 more source
Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy
Advanced Science, EarlyView.A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan +9 more
wiley +1 more source
Advanced Science, EarlyView.In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu +7 more
wiley +1 more source
Mannitol vs. methacholine in the evaluation of airway responsiveness in bakers’ asthma
International Journal of Occupational Medicine and Environmental Health, 2020 Objectives Various indirect or direct airway challenge tests are used to measure nonspecific bronchial hyper-responsiveness (NSBHR). The evaluation of NSBHR in diagnosing occupational asthma (OA) is performed, e.g., to monitor the specific inhalation ...
Ewa Nowakowska-Świrta +3 more
doaj +1 more source
ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites
Advanced Science, EarlyView.ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng +9 more
wiley +1 more source
, 2016 The cyclopolymerization of 1,2:5,6-dianhydro-d-mannitol (1) was carried out using BF3·OEt2 and t-BuOK. Although the anionic polymerization tended to form gels, the cationic polymerization proceeded through the proton-transfer reaction mechanism to ...
Tomoko Imai (2718577) +4 more
core +1 more source
Advanced Science, EarlyView.Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan +7 more
wiley +1 more source
BMC Cancer, 2007 Background Combination of platinum derivatives with paclitaxel is currently the standard front line regimen for patients with epithelial ovarian carcinoma, and represents also an active regimen in patients with metastatic breast or unknown primary ...
Tichá Alena +5 more
doaj +1 more source
Inhaled mannitol for cystic fibrosis.
, 2015 BACKGROUND: Several agents are used to clear secretions from the airways of people with cystic fibrosis. Inhaled dry powder mannitol is now available in Australia and some countries in Europe.
Dwyer, Tiffany +3 more
core +1 more source