Results 61 to 70 of about 43,575 (199)

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Computational insights into the circular permutation roles on ConA binding and structural stability

Current Research in Structural Biology
The mechanisms behind Concanavalin A (ConA) circular permutation have been under investigation since 1985. Although a vast amount of information is available about this lectin and its applications, the exact purpose of its processing remains unclear.
Vinicius J.S. Osterne, Vanir R. Pinto-Junior, Messias V. Oliveira, Kyria S. Nascimento, Els J.M. Van Damme, Benildo S. Cavada   +5 more
doaj   +1 more source

A Novel High-Mannose Specific Lectin from the Green Alga Halimeda renschii Exhibits a Potent Anti-Influenza Virus Activity through High-Affinity Binding to the Viral Hemagglutinin

Marine Drugs, 2017
We have isolated a novel lectin, named HRL40 from the green alga Halimeda renschii. In hemagglutination-inhibition test and oligosaccharide-binding experiment with 29 pyridylaminated oligosaccharides, HRL40 exhibited a strict binding specificity for high-
Jinmin Mu, Makoto Hirayama, Yuichiro Sato, Kinjiro Morimoto, Kanji Hori   +4 more
doaj   +1 more source

A Novel Diagnostic Approach for Hepatocellular Carcinoma Using Glycosylated Ferritin

Hepatology Research, EarlyView.
The percentage of glycosylated ferritin relative to total ferritin (%GF) is a novel biomarker for hepatocellular carcinoma (HCC), showing diagnostic performance comparable to that of AFP and DCP. We developed the GFAD index by integrating age, sex, %GF, AFP, and DCP, achieving improved diagnostic accuracy with high sensitivity and specificity. ABSTRACT
Akiyo Ishiguro, Yutaka Suehiro, Issei Saeki, Maho Egusa, Norikazu Tanabe, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Yuki Kunimune, Toshihiko Kobayashi, Mitsuaki Nishioka, Taro Takami, Takahiro Yamasaki   +11 more
wiley   +1 more source

High mannose-binding antiviral lectin PFL from Pseudomonas fluorescens Pf0-1 promotes cell death of gastric cancer cell MKN28 via interaction with α2-integrin.

PLoS ONE, 2012
Novel anti-HIV lectin family which shows a strict binding specificity for high mannose glycans has been found in lower organisms. The bacterial orthologue has been identified in the genome of Pseudomonas fluorescens Pf0-1 and the gene coding a putative ...
Yuichiro Sato, Kinjiro Morimoto, Takanori Kubo, Kazuyoshi Yanagihara, Toshio Seyama   +4 more
doaj   +1 more source

PlantRG: A Comprehensive and User‐Friendly Database for Plant Resistance Gene Analogs (RGAs)

Plant Biotechnology Journal, EarlyView.
ABSTRACT Resistance genes are critical for plant defence against biotic stresses, and building a comprehensive, integrated data resource platform for these genes holds great significance for plant research and agriculture. Here, we developed PlantRG (http://plantrg.bio2db.com), a user‐friendly plant resistance gene database, which is built on 2 163 397
Jinghua He, Xiao Ma, Rui Cao, Zhuo Liu, Chenhao Zhang, Wei Chen, Lusheng Guo, Zipeng Meng, Rong Zhou, Xiaoming Song   +9 more
wiley   +1 more source

Transcript correlation analysis for the identification of novel plant genes involved in iron metabolism and beyond: what next?

Plant Biology, EarlyView.
Transcript correlation analysis allowed the identification of several key nodes in the complex regulatory network of plant iron metabolism. Abstract Arabidopsis thaliana was the first plant genome to be fully sequenced, almost a quarter of a century ago, thanks to The Arabidopsis Genome Initiative, with contributions from scientists worldwide.
I. Murgia, P. Morandini
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Mannose-binding lectin and the kidney [PDF]

Nephrology Dialysis Transplantation, 2007
Anja, Roos, Mohamed R, Daha, Johannes, van Pelt, Stefan P, Berger   +3 more
openaire   +2 more sources

Altered N-Linked Glycosylation in Follicular Lymphoma and Chronic Lymphocytic Leukemia: Involvement in Pathogenesis and Potential Therapeutic Targeting

Frontiers in Immunology, 2017
B-cell antigen receptor (BCR) expression is indispensable for survival of most B-cell malignancies. In follicular lymphoma (FL), N-linked glycosylation sites are introduced in the immunoglobulin (Ig) variable region genes.
Nurit Hollander, Joseph Haimovich
doaj   +1 more source