Results 121 to 130 of about 50,060 (273)
Two Lineages of Mannose-Binding Lectin-Associated Serine Protease (MASP) in Vertebrates [PDF]
Yuichi Endo+7 more
openalex +1 more source
In this study, we present a calix[4]arene building block suitable for modular solid‐phase polymer synthesis and the preparation of functional glycocalix[4]arene. This allows us to incorporate carbohydrate ligands and further functionalities, such as alkynes at a specific position at the upper or lower rim of the calix[4]arene as demonstrated for the ...
Alisa Kayser+8 more
wiley +1 more source
Mannose‐Binding Lectin Plasma Levels and Gene Polymorphisms inPlasmodium falciparumMalaria [PDF]
Adrian J. F. Luty+2 more
openalex +1 more source
The stereochemical diversity of the “glycan code” enables similar chiral motifs to arise from both D‐ and L‐sugars. Focused on DC‐SIGN–glycan recognition, two diverse monosaccharide scaffolds, D‐Man (D‐Rha) and L‐Gal (L‐Fuc), maintain the exquisite stereochemistry encoded in the minimal binding epitope.
J. Daniel Martínez+7 more
wiley +1 more source
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray+2 more
wiley +1 more source
Microbiome Single Cell Atlases Generated with a Commercial Instrument
Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li+8 more
wiley +1 more source
What contributes to an effective mannose recognition domain?
In general, carbohydrate–lectin interactions are characterized by high specificity but also low affinity. The main reason for the low affinities are desolvation costs, due to the numerous hydroxy groups present on the ligand, together with the typically ...
Christoph P. Sager+4 more
doaj +1 more source
Cutting Edge: Complement-Activating Complex of Ficolin and Mannose-Binding Lectin-Associated Serine Protease [PDF]
Misao Matsushita+2 more
openalex +1 more source
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal+4 more
wiley +1 more source
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost+9 more
wiley +1 more source