Results 121 to 130 of about 50,060 (273)

Two Lineages of Mannose-Binding Lectin-Associated Serine Protease (MASP) in Vertebrates [PDF]

open access: bronze, 1998
Yuichi Endo   +7 more
openalex   +1 more source

A Modular Solid Phase Synthesis Approach for Glycocalix[4]Arene Derivatives and Their Multivalent Presentation on Ultrasmall Gold Nanoparticles.

open access: yesChemistry – A European Journal, Volume 31, Issue 40, July 17, 2025.
In this study, we present a calix[4]arene building block suitable for modular solid‐phase polymer synthesis and the preparation of functional glycocalix[4]arene. This allows us to incorporate carbohydrate ligands and further functionalities, such as alkynes at a specific position at the upper or lower rim of the calix[4]arene as demonstrated for the ...
Alisa Kayser   +8 more
wiley   +1 more source

Glycans and Chirality: Stereoselectivity at the Core of DC‐SIGN's Recognition. A Novel View of the Optimum Minimal Ligand Epitope

open access: yesChemistry – A European Journal, Volume 31, Issue 37, July 2, 2025.
The stereochemical diversity of the “glycan code” enables similar chiral motifs to arise from both D‐ and L‐sugars. Focused on DC‐SIGN–glycan recognition, two diverse monosaccharide scaffolds, D‐Man (D‐Rha) and L‐Gal (L‐Fuc), maintain the exquisite stereochemistry encoded in the minimal binding epitope.
J. Daniel Martínez   +7 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

Microbiome Single Cell Atlases Generated with a Commercial Instrument

open access: yesAdvanced Science, Volume 12, Issue 27, July 17, 2025.
Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li   +8 more
wiley   +1 more source

What contributes to an effective mannose recognition domain?

open access: yesBeilstein Journal of Organic Chemistry, 2017
In general, carbohydrate–lectin interactions are characterized by high specificity but also low affinity. The main reason for the low affinities are desolvation costs, due to the numerous hydroxy groups present on the ligand, together with the typically ...
Christoph P. Sager   +4 more
doaj   +1 more source

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 7, Page 1710-1723, July 2025.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal   +4 more
wiley   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 242-251, July 2025.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost   +9 more
wiley   +1 more source

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