Results 141 to 150 of about 49,958 (268)

Enhanced Antiviral and Opsonic Activity of a Human Mannose-Binding Lectin and Surfactant Protein D Chimera [PDF]

, 2000
Mitchell R. White, Erika C. Crouch, Donald Chang, Kedarnath N. Sastry, Ning Guo, Georg Engelich, Kazue Takahashi, R. Alan B. Ezekowitz, Kevan L. Hartshorn   +8 more
openalex   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 242-251, July 2025.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese [PDF]

, 2000
Takahiko Horiuchi, Hiroshi Tsukamoto, Chika Morita, Takuya Sawabe, Shin‐ichi Harashima, Hitoshi Nakashima, Hisaaki Miyahara, Chinami Hashimura, Masayoshi Kondo   +8 more
openalex   +1 more source

Recent Advances in the Characterization of Food Biomacromolecules: Polysaccharide, Protein, and Lipid

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Polysaccharides, proteins, and lipids are key biomacromolecules that determine the structure, function, and nutritional value of food systems. Recent advances in spectroscopic, chromatographic, and imaging techniques have significantly enhanced our ability to characterize their complex structures and dynamic behaviors.
Seid Reza Falsafi, Julia Sebastian, Rosana Colussi, Lucas Ávila do Nascimento, Tansel Kemerli‐Kalbaran, Meral Yildirim‐Yalcin, Ivan Adrian Garcia‐Galicia, Selin Sahin, Alma Delia Alarcon‐Rojo   +8 more
wiley   +1 more source

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

MedComm, Volume 6, Issue 7, July 2025.
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi, Haipeng Jiang, Yiyuan Yin, Xinyu Zhou, Yiyouyou Shao, Yongsheng Li, Jianhua Rao   +6 more
wiley   +1 more source

Mannose-Binding Lectin Binds to a Range of Clinically Relevant Microorganisms and Promotes Complement Deposition [PDF]

, 2000
Olaf Neth, Dominic Jack, Alister W. Dodds, H Holzel, Nigel Klein, Malcolm Turner   +5 more
openalex   +1 more source

Traditional and Emerging Physical Processing Technologies: Applications and Challenges in Allergen Control of Animal and Plant Proteins

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 4, July 2025.
ABSTRACT Under global food shortages and environmental challenges, the food industry is shifting from animal to plant proteins, coinciding with a rising prevalence of food allergies. Structural and functional differences between animal and plant proteins significantly influence their allergenic potential.
Lili Zhang, Vijaya Raghavan, Jin Wang
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of HSK39297 in Chinese Healthy Subjects: A Phase 1 Clinical Trial

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT HSK39297 is a novel complement factor B inhibitor, and this phase 1 trial was designed to assess its pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability in healthy Chinese subjects. This study included 46 subjects in the single ascending dose (SAD) part (50–600 mg) and 50 subjects in the multiple ascending dose (MAD) part ...
Yuyang Dai, Feng Wu, Siyang Ni, Xiaojun Hu, Ying Han, Ying Jiao, Huan Lu, Yilin Liu, Lingling Wang, Yunfei Lin, Meixia Chen, Chao Wang, Qinghe Wu, Fangqiong Li, Laichun Lu   +14 more
wiley   +1 more source

A single-pass type I membrane protein, mannose-specific L-type lectin, potentially involved in the adhesion and invasion of Cryptosporidium parvum

Parasite
Cryptosporidium is a globally distributed zoonotic protozoan parasite that can cause severe diarrhea in humans and animals. L-type lectins are carbohydrate-binding proteins involved in multiple pathways in animals and plants, including protein ...
Zhang Xiaotian, Sun Songying, Zhao Wenchao, Wang Luyang, Liang Guanda, Wang Yuexin, Cai Baiyi, Zhang Longxian, Li Xiaoying, Zhang Sumei   +9 more
doaj   +1 more source

Mannose Binding Lectin Polymorphisms are Associated With Early Age of Disease Onset and Autoimmunity in Common Variable Immunodeficiency [PDF]

, 2000
Charles G. Mullighan, Маршалл, Welsh   +2 more
openalex   +1 more source