Results 221 to 230 of about 15,589 (264)

Mannose binding lectin gene polymorphisms and asthma

Clinical & Experimental Allergy, 2007
SummaryBackground Bronchial asthma is a chronic inflammatory disorder of the airways. Recently, it has been suggested that complement plays significant roles in asthma. Mannose‐binding lectin (MBL) is one of the key molecules in complement activation pathways that are associated with several infectious and immune disorders.Subjects and method
X, Wang, J, Saito, Y, Tanino, T, Ishida, T, Fujita, M, Munakata   +5 more
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Anti-microbial activities of mannose-binding lectin

Biochemical Society Transactions, 2003
Mannose-binding lectin (MBL; also known as mannan-binding lectin) is involved in first-line defence by binding to bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection and then initiating a range of host responses. Currently, we have been unable to extrapolate from what we know of the biochemistry of MBL binding to ...
D L, Jack, M W, Turner
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Mannose-Binding Lectin Genes

2008
Abstract Mannose-binding lectin (MBL) is an important component of the innate immune system. MBL belongs to the family of proteins called collectins, which contain both collagen-like domains and C-type lectin domains. The human collectin family includes MBL and lung surfactant proteins A and D (Holmskov et al., 1994; Lu, 1997; Lu et al.,
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Mannose‐binding lectin: biology and clinical implications

Internal Medicine Journal, 2005
Abstract The innate host defence molecule mannose‐binding lectin (MBL) has attracted great interest as a potential candidate for passive immunotherapy to prevent infection. MBL is a multimeric lectin that recognizes a wide array of pathogens independently of specific antibody, and initiates the lectin pathway of complement activation.
D L, Worthley, P G, Bardy, C G, Mullighan   +2 more
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Mannose binding lectin: Genetics and autoimmune disease

Autoimmunity Reviews, 2005
Mannose binding lectin (MBL) is a serum protein with structure and functions similar to those of complement factor C1q, and is a key molecule in innate immunity. Interestingly, absence or extremely low concentration of serum MBL (MBL deficiency) seems to be a risk factor for occurrence of autoimmune diseases, in particular systemic lupus erythematosus.
Akito, Tsutsumi, Reiko, Takahashi, Takayuki, Sumida   +2 more
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Mannose-Binding Lectins in Cerebrum Development

2003
The nervous system is so complex that it is not ordinarily considered as an interesting model for studying cellular mechanisms. However, its morphology (at least in some well-defined areas) provides essential information because cells are polarised: cell body, axons and dendrites can be easily identified in vivo, an essential property when studies are ...
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Mannose-binding lectin shows its value

Trends in Immunology, 2001
The plasma protein mannose-binding lectin (MBL) binds to carbohydrate moieties found on the surface of a range of microorganisms. Once bound, the protein activates complement, leading to increased phagocytosis and lysis of the foreign surface. Low levels of MBL are common to all populations, but the relative importance of this component of the innate ...
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Mannose-binding lectin

The Lancet, 2002
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Glycomimetics for the inhibition and modulation of lectins

Chemical Society Reviews, 2023
, Petra Menova, Elena Shanina
exaly  

Mannose-binding lectin gene-2 polymorphisms and serum mannose-binding lectin levels in Behçet's disease.

Clinical and experimental rheumatology, 2010
Behçet's disease (BD) is an autoimmune disease with an unknown etiology and mannose-binding lectin (MBL) is a pattern recognition receptor in the innate immune system, which is associated with some autoimmune diseases. We investigated MBL2 gene polymorphisms and serum MBL levels in BD patients and controls.MBL2 gene polymorphisms in exon 1 (MBL2 54 Gly/
J, Kim, C H, Im, E H, Kang, E Y, Lee, Y J, Lee, K S, Park, Y W, Song   +6 more
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