Results 171 to 180 of about 224,774 (318)

Cell‐Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis

Aging Cell, EarlyView.
We have validated the selective upregulation of LAMP1 in SEN in culture, and the percentage of Lamp1+ cells increases in various tissues with age, as well as in fibrotic lungs following BLM instillation. The RNA‐Sequencing analysis of the Lamp1‐enriched populations confirmed the enrichment of senescence‐related genes.
Gabriel Meca‐Laguna, Michael Qiu, Yafei Hou, Anna Barkovskaya, Apoorva Shankar, Bhavna Dixit, Michael J. Rae, Amutha Boominathan, Amit Sharma   +8 more
wiley   +1 more source

Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases

Molecular Neurobiology, 2017
Yi Wang, R. Macdonald, G. Thinakaran, S. Kar   +3 more
semanticscholar   +1 more source

Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Nature Communications
Targeting proteins to their final cellular destination requires transport mechanisms and nearly all lysosomal enzymes reach the lysosome via the mannose-6-phosphate receptor pathway.
Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, Priyadarshini Ravindran, Dustin J. E. Huard, Eileen Socher, Lisa A. Schildmeyer, Raquel L. Lieberman, Wim Versées, Arne Moeller, Friederike Zunke, Philipp Arnold   +11 more
doaj   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Supplementation of Oocytes by Microinjection with Extra Copies of mtDNA Alters Metabolite Profiles and Interactions with Expressed Genes in a Tissue-Specific Manner

Biomolecules
Mitochondrial DNA (mtDNA) supplementation can rescue poor oocyte quality and overcome embryonic arrest. Here, we investigated a series of sexually mature pigs generated through autologous and heterologous mtDNA supplementation.
Eryk Andreas, Alexander Penn, Takashi Okada, Justin C. St. John   +3 more
doaj   +1 more source

Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells. [PDF]

Sci Rep, 2023
Aguilera AC, Leiva N, Alvarez PA, Pulcini G, Pereyra LL, Morales CR, Sosa MÁ, Carvelli L.   +7 more
europepmc   +1 more source

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor.

, 1988
Wieland Kieß, G D Blickenstaff, Mark Sklar, Cheryl L. Thomas, S. Peter Nissley, G G Sahagian   +5 more
openalex   +1 more source

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

Long‐Term Clinical‐Pathologic Results of Enzyme Replacement Therapy in Prehypertrophic Fabry Disease Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The limited ability of enzyme replacement therapy (ERT) in removing globotriaosylceramide from cardiomyocytes is recognized for advanced Fabry disease cardiomyopathy (FDCM).
Andrea Frustaci, Romina Verardo, Nicola Galea, Maria Alfarano, Michele Magnocavallo, Livia Marchitelli, Luigi Sansone, Manuel Belli, Mario Cristina, Emanuela Frustaci, Matteo Antonio Russo, Cristina Chimenti   +11 more
doaj   +1 more source

Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras. [PDF]

Anim Cells Syst (Seoul), 2022
Seo J, Oh DB.
europepmc   +1 more source