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Expedited synthesis of mannose-6-phosphate containing oligosaccharides

Carbohydrate Research, 2022
Currently, the reaction toolbox for the functionalization of glycans assembled on solid-phase is quite limited. Automated (1 h) and manual (overnight) phosphorylation protocols that enable the solid-phase synthesis of oligosaccharides containing up to two mannose-6-phosphates are presented.
Sletten, E.   +4 more
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Human DNase I Contains Mannose 6-Phosphate and Binds the Cation-Independent Mannose 6-Phosphate Receptor

Biochemistry, 1998
DNase I isolated from human urine (hDNase) or expressed in Chinese hamster ovary (CHO) cells contains mannose-phosphorylated oligosaccharides. hDNase binds to a column of immobilized cation-independent mannose 6-phosphate receptor, with the strongest binding exhibited by the protein bearing diphosphorylated oligosaccharides. The binding is inhibited by
J, Cacia, C P, Quan, R, Pai, J, Frenz
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Chemical Synthesis of N-Linked Glycans Carrying Both Mannose-6-phosphate and GlcNAc-Mannose-6-phosphate Motifs

The Journal of Organic Chemistry, 2011
Mannose-6-phosphate (M6P) containing N-linked glycans are the essential targeting signals for hydrolases sorting in eukaryotic cells. To facilitate their structural and binding analyses, a highly efficient and convergent method has been developed to prepare complex N-linked glycans with well-defined M6P and N-acetylglucosamine (GlcNAc)-M6P motifs, a ...
Yunpeng, Liu, Gong, Chen
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Mannose-6-phosphate isomerase polymorphism in baboon erythrocytes

Biochemical Genetics, 1990
Although erythrocytic mannose-6-phosphate isomerase (MPI) has been reported to be undetectable in mammals, we have demonstrated that sufficient activity is present in some species to enable its electrophoretic analysis. A survey of MPI from 2656 baboons revealed four allelic isozymes which segregated codominantly in pedigreed families.
J L, VandeBerg, M J, Aivaliotis
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The Cation-Dependent Mannose 6-Phosphate Receptor

2001
The 46kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300kDa cation-independent mannose 6-phosphate receptor (CI-MPR) are the sole members of the P-type family of lectins, which derive their name from their ability to bind phosphorylated mannose residues.
J J, Kim, N M, Dahms
openaire   +2 more sources

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