Results 61 to 70 of about 58,594 (258)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Monogenetic Near‐Island Seamounts in the Galápagos Archipelago

Geochemistry, Geophysics, Geosystems, 2020
Rarely have small seamounts on the flanks of hotspot derived ocean‐island volcanoes been the targets of sampling, due to sparse high‐resolution mapping near ocean islands.
D. M. Schwartz, V. D. Wanless, S. A. Soule, M. D. Schmitz, M. D. Kurz   +4 more
doaj   +1 more source

Ruthenium‐Titania Interface‐Mediated Water Activation for High Turnover Frequency in Alkaline Hydrogen Evolution

Carbon Energy, EarlyView.
Heterostructured interfaces can accelerate hydrogen evolution by improving water dissociation, yet their underlying mechanisms remain unclear. This study combines in situ Raman spectroscopy and density functional theory to reveal how the RuO2/TiO2 interface promotes both water dissociation and hydrogen adsorption, providing new insights into the ...
Dwi Sakti Aldianto Pratama, Andi Haryanto, Hyun Woo Lim, Chan Woo Lee   +3 more
wiley   +1 more source

Pulsated Global Hydrogen and Methane Flux at Mid‐Ocean Ridges Driven by Pangea Breakup

Geochemistry, Geophysics, Geosystems, 2020
Molecular hydrogen production occurs through the serpentinization of mantle peridotite exhumed at mid‐ocean ridges. Hydrogen is considered essential to sustain microbial life in the subsurface; however, estimates of hydrogen flux through geological time ...
Andrew S. Merdith, Pablo García delReal, Isabelle Daniel, Muriel Andreani, Nicky M. Wright, Nicolas Coltice   +5 more
doaj   +1 more source

The Rich Chemistry of Ionized Methanol With Sulfur Dioxide: Pathways to Prebiotic and Elusive Species in Earth's Atmosphere and Space

Chemistry – A European Journal, EarlyView.
The reaction between the methanol radical cation and sulfur dioxide is remarkably fast and forms several ionic and neutral products (HOSOH+, CH2OSO+, CH2OH+, CH2O, H2O, HSO2). The chemistry goes beyond simple proton or hydrogen transfer, revealing a close interaction between the two species, relevant to atmospheric and astrochemical environments where ...
Mauro Satta, Daniele Catone, Mattea Carmen Castrovilli, Antonella Cartoni   +3 more
wiley   +1 more source

Trace element mass balance in hydrous adiabatic mantle melting: The Hydrous Adiabatic Mantle Melting Simulator version 1 (HAMMS1)

Geochemistry, Geophysics, Geosystems, 2014
A numerical mass balance calculation model for the adiabatic melting of a dry to hydrous peridotite has been programmed in order to simulate the trace element compositions of basalts from mid‐ocean ridges, back‐arc basins, ocean islands, and large ...
Jun‐Ichi Kimura, Hiroshi Kawabata
doaj   +1 more source

Influencing Parameters at Drum Screens for Packaging Screening

Chemie Ingenieur Technik, EarlyView.
Drum (trommel) screens are extensively utilized in the classification of packaging waste according to its particle size. The present study aims to quantify the size‐classification behaviour of elongated, hollow packaging‐like items (representing bottles, tubes and cups) using cylindrical and tubular test pieces.
Konstantin Schinkel, Bastian Küppers, Dirk Burth, Michael Rudolf Sommer, Sven Sängerlaub   +4 more
wiley   +1 more source

Evaluation of Small Molecular Polypeptides from the Mantle of Pinctada Martensii on Promoting Skin Wound Healing in Mice

Molecules, 2019
Skin wound healing, especially chronic wound healing, is a common challenging clinical problem. It is urgent to broaden the sources of bioactive substances that can safely and efficiently promote skin wound healing.
Faming Yang, Xiaoming Qin, Ting Zhang, Haisheng Lin, Chaohua Zhang   +4 more
doaj   +1 more source

Peroxodisulfate‐Enhanced Leaching of Deep‐Sea Manganese Crusts and Sulfides

Chemie Ingenieur Technik, EarlyView.
Ammonium peroxodisulfate enables efficient leaching of deep‐sea manganese crusts and massive sulfides while offering electrolytic recycling. High leaching yields for V, Mn, Co, Mo, Sn, and W, along with complete leaching of As and Sb, highlight its potential as a powerful and sustainable oxidant for marine resource processing.
Bastian Hansel, Lucas Thumeyer, Ebbe H. Hartz, Håvard Hallås Stubseid, Peter Fröhlich, Martin Bertau   +5 more
wiley   +1 more source