Results 71 to 80 of about 172,406 (286)

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

Active Degassing of Deeply Sourced Fluids in Central Europe: New Evidences From a Geochemical Study in Serbia

Geochemistry, Geophysics, Geosystems, 2021
We report on the results of an extensive geochemical survey of fluids released in the Vardar zone (central‐western Serbia), a mega‐suture zone at the boundary between Eurasia and Africa plates.
P. Randazzo, A. Caracausi, A. Aiuppa, C. Cardellini, G. Chiodini, W. D'Alessandro, L. Li Vigni, P. Papic, G. Marinkovic, A. Ionescu   +9 more
doaj   +1 more source

The energetics of melting fertile heterogeneities within the depleted mantle [PDF]

To explore the consequences of mantle heterogeneity for primary melt production, we develop a mathematical model of energy conservation for an upwelling, melting body of recycled oceanic crust embedded in the depleted upper mantle.
Katz, R. F., Rudge, John F.
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Some features of the structure of the mantle of the Eastern Mediterranean and their geodynamic interpretation

Геофизический журнал, 2016
We consider specific velocity anomalies and the corresponding mantle structures of the East Mediterranean-Black Sea-Caspian region. The anomalies are located on latitudinal and longitudinal seismic tomography sections obtained by constructing 3D P ...
O. B. Gintov, T. A. Tsvetkova, I. V. Bugaenko, A. V. Murovskaya   +3 more
doaj   +1 more source

Large-scale adaptive mantle convection simulation [PDF]

A new generation, parallel adaptive-mesh mantle convection code, Rhea, is described and benchmarked. Rhea targets large-scale mantle convection simulations on parallel computers, and thus has been developed with a strong focus on computational efficiency
Wilcox, Lucas C., Gurnis, Michael, Ghattas, Omar, Burstedde, Carsten, Tan, Eh, Alisic, Laura, Stadler, Georg   +6 more
core   +1 more source

The Rich Chemistry of Ionized Methanol With Sulfur Dioxide: Pathways to Prebiotic and Elusive Species in Earth's Atmosphere and Space

Chemistry – A European Journal, EarlyView.
The reaction between the methanol radical cation and sulfur dioxide is remarkably fast and forms several ionic and neutral products (HOSOH+, CH2OSO+, CH2OH+, CH2O, H2O, HSO2). The chemistry goes beyond simple proton or hydrogen transfer, revealing a close interaction between the two species, relevant to atmospheric and astrochemical environments where ...
Mauro Satta, Daniele Catone, Mattea Carmen Castrovilli, Antonella Cartoni   +3 more
wiley   +1 more source

Influencing Parameters at Drum Screens for Packaging Screening

Chemie Ingenieur Technik, EarlyView.
Drum (trommel) screens are extensively utilized in the classification of packaging waste according to its particle size. The present study aims to quantify the size‐classification behaviour of elongated, hollow packaging‐like items (representing bottles, tubes and cups) using cylindrical and tubular test pieces.
Konstantin Schinkel, Bastian Küppers, Dirk Burth, Michael Rudolf Sommer, Sven Sängerlaub   +4 more
wiley   +1 more source