Results 121 to 130 of about 1,059,053 (303)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Frontiers in Integrative NeuroscienceIntroductionMotor skill difficulties are common in autistic children and are related to daily living skills (DLS). However, it remains unclear which specific motor tasks are most likely to impact overall DLS.
Emily C. Skaletski +5 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Contour Cutting with Scissors – A Study on Manual Dexterity and Time Management
Bulletin of the Transilvania University of Braşov: Series VII: Social Sciences, LawThe article presents a study on the relationship between manual dexterity and time management, considering contour cutting with scissors as an indicator of manual dexterity.
Elena-Simona Indreica
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
In-demand skills: a shield against automation—evidence from online job vacancies
Journal for Labour Market ResearchThis paper investigates how in-demand skills, advertised wages, and occupational exposure to automation co-evolve in Slovakia’s online labor market. Drawing on data covering nearly the full universe of online job vacancies posted in Slovakia in 2022, the
Tomáš Oleš
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Frontiers in CognitionIntroductionThe present study employed the Jacobson-Truax reliable change index (RCI) to examine the effectiveness of a 4-week manual dexterity training program embedded in a socially enriched group setting to improve working memory performance ...
Christina Stuhr +2 more
doaj +1 more source
Administrative automation in a scientific environment [PDF]
Although the scientific personnel at GSFC were advanced in the development and use of hardware and software for scientific applications, resistance to the use of automation or purchase of terminals, software and services, specifically for administrative ...
Jarrett, J. R.
core +1 more source
Research Brief: The Role of Tasks and Skills in Explaining the Disability Pay Gap [PDF]
, 2014 A disparity in pay exists between workers with and without disabilities. This gap persists even in analyses that control for a variety of factors and incorporate compensation benefits other than wages and salaries.
Barrington, Linda +3 more
core +1 more source