Results 91 to 100 of about 19,710 (294)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Feature Recognition for Manufacturability Analysis [PDF]

, 1994
While automated recognition of features has been attempted for a wide range of applications, no single existing approach possesses the functionality required to perform manufacturability analysis.
Gupta, Satyandra K., Regli, W.C., Nau, D.S.   +2 more
core   +1 more source

Optimization of Manufacturable Porous Infill Structure Using Differentiable Voronoi Diagram

Inventions
This paper presents a novel method for designing manufacturable porous infill structures using a Voronoi-based topology optimization framework. By integrating discrete Voronoi representations into density-based topology optimization in a differentiable ...
Qinxue Wang, Yanyan Li, Xin He, Weiming Wang   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Feature extraction from solid model for manufacturability assessment

, 2018
: "Assessment of manufacturability of a design with minimum human intervention is in increasing demand. It is, however, very difficult to investigate manufacturability problems with analytical tools in most of the manufacturing processes.
Carnegie Mellon University.Engineering Design Research Center. (5047289), Friedrich B. Prinz (2296894), Jyh-Huei Chern (5371148), Young Choi (5358479)   +3 more
core   +1 more source

CAPP MODEL OF FUZZY SYSTEMS AND FUZZY MANUFACTURABILITY [PDF]

, 2013
They give the soles of technological design process using fuzzy logic for metal cutting, referring to the determination of all the elements of production process: the dimensions and quality of the workpiece material, the sequence and scope of ...
Radivoje Antić, Slavica Cvetković, Milan Cvetković, Branko Pejović   +3 more
core   +1 more source

A generalized methodology for manufacturability evaluation

, 1993
Vita.In a design for manufacturing (DFM) approach the designer has to consider the interactions between the various parameters in the design and the ease with which it can be manufactured, very early in the design process.
Shankar, Srinivasa Ravi
core   +1 more source

From Biological Models to Industrial Production: How Industry 4.0 Enables the Manufacturability and Scalability of Biomimetic Design

Biomimetics
The industrial relevance of biomimetic design rests on whether a biological principle can be converted into an engineering solution that is manufacturable, verifiable, scalable, and traceable in operation.
Alaeddin Koska
doaj   +1 more source