Results 71 to 80 of about 19,710 (294)

Assessment of production manufacturability of the design in the product life cycle

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2020
On the basis of technical and economic analysis of the properties of relations between design and technological solutions, a method for the integral assessment of production manufacturability by combining individual manufacturability coefficients at ...
B. M. Bazrov, M. L. Kheifetz, V. L. Hurevich, N. N. Popok   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comprehensive Assessment of the Manufacturability of Products

, 2023
Introduction. The assessment of the manufacturability of products – as a stage of production planning and a key aspect of the development of modern industrial machining systems — is an urgent task of modern mechanical engineering.
P. Yu. Bochkaryov, L. G. Bokova, R. D. Korolev   +2 more
core   +1 more source

Interpreting Product Designs for Manufacturability Evaluation

, 1993
The ability to quickly introduce new quality products is a decisive factor in capturing market share. Because of pressing demands to reduce lead time, analyzing the manufacturability of the proposed design has become an important step in the design stage.
Gupta, Satyandra K., Nau, D.S., Zhang, G.M.   +2 more
core   +1 more source

Manufactured Inequality [PDF]

Journal of Labor Economics, 1997
Many discrete life choices--where to live, what kind of job to hold, and consumption lifestyle--are stratified by income. Stratification and sorting often manifest state-dependent preferences in which the marginal utility of income (consumption) depends on the outcome of prior choices.
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ETHODOLOGY FOR ENSURING MANUFACTURABILITY OF UAV WITH ULTRASONIC POSITIONING IN LIMINITED SPACE CONDITIONS

Надежность и качество сложных систем
Background. The manufacturability technique for UAVs with local positioning described in this paper can be used to coordinate several drones, allowing to correct their routes and avoid collisions in the local space while ensuring specified technical and ...
Arina A. Adamova
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Automated Manufacturability Evaluation for Microwave Modules

, 1992
Current competitive trends in manufacturing require full implementation of concurrent engineering, i.e. the consideration of all relevant aspects of a product's life cycle in the design phase.
Rathbun, H.J.
core   +1 more source