Results 51 to 60 of about 19,710 (294)
Nihon Kikai Gakkai ronbunshu, 2017 This paper proposes a scheme for imposing geometrical constraints in topology optimization for molding and milling so that optimal configurations that guarantee manufacturability can be obtained, based on the fictitious physical model. First, a level set-
Yuki SATO +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Cloud Manufacturing Application for Additive Manufacturing Methods
2019 IEEE International Conference on Mechatronics (ICM), 2019 Over the past years, the manufacturing industry has witnessed a great enhancement in the field of Additive Manufacturing that allows forming an inchoate market to produce custom-made products with low unit costs. At the same time, everyone may be a designer as well. However, the required equipment is only accessible for all the people.
Vahid Haseltalab, Ulas Yaman
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
SOME PROBLEMS OF ECONOMIC STABILITY UNDER CONDITIONS OF HIGH TURBULENCE ENVIRONMENT
Север и рынок: формирование экономического порядка, 2022 The article discusses specific features of oilfield services company functioning as a part of Russian oilfield services which are the driver of Russian oil-and-gas industry.
Alexey V. Beloshitskiy
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Considering Manufacturability in the Design of Deployable Origami-Adapted Mechanisms [PDF]
, 2017 Primary barriers to greater implementation of deployable origami-adapted mechanisms are their manufacturability and robustness. This paper discusses manufacturability in the design of such mechanisms through presenting and examining three examples ...
Crampton, Erica B., Magleby, Spencer P.
core +1 more source
Rotor Topology Optimization for Interior Permanent Magnet Machines Considering Manufacturability
Rotor topology optimization becomes a critical tool in interior permanent magnet (IPM) machine design for better performance and material utilization. Existing optimization methods mainly focus on electromagnetic performance, neglecting manufacturability
Meng Xia (29894) +3 more
core +6 more sources
Development of technology for automated generation of CAD design rule check Program
Nihon Kikai Gakkai ronbunshuAutomated design rule checking (DRC) is a critical component of Design for X (DfX) strategies; however, establishing general-purpose automated systems in mechanical design remains difficult due to the high degrees of freedom in 3D shapes and the ...
Junya YOSHIDA +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source