Results 41 to 50 of about 7,374 (265)
Nihon Kikai Gakkai ronbunshu, 2017 This paper proposes a scheme for imposing geometrical constraints in topology optimization for molding and milling so that optimal configurations that guarantee manufacturability can be obtained, based on the fictitious physical model. First, a level set-
Yuki SATO +3 more
doaj +1 more source
SOME PROBLEMS OF ECONOMIC STABILITY UNDER CONDITIONS OF HIGH TURBULENCE ENVIRONMENT
Север и рынок: формирование экономического порядка, 2022 The article discusses specific features of oilfield services company functioning as a part of Russian oilfield services which are the driver of Russian oil-and-gas industry.
Alexey V. Beloshitskiy
doaj +1 more source
Resources in manufacturing [PDF]
, 2019 Standards and ontologies for manufacturing differently understand resources. Because of this heterogeneity, misunderstandings arise concerning the basic features that characterise them. The purpose of the paper is to shed some light on the ontology of resources to strive the development of computational models for manufacturing.
Sanfilippo Emilio M +2 more
openaire +3 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A Cloud Manufacturing Application for Additive Manufacturing Methods
2019 IEEE International Conference on Mechatronics (ICM), 2019 Over the past years, the manufacturing industry has witnessed a great enhancement in the field of Additive Manufacturing that allows forming an inchoate market to produce custom-made products with low unit costs. At the same time, everyone may be a designer as well. However, the required equipment is only accessible for all the people.
Vahid Haseltalab, Ulas Yaman
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Developability considerations for bispecific and multispecific antibodies
mAbsBispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. Early assessment of
Alaa Amash +9 more
doaj +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source