Results 41 to 50 of about 19,710 (294)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Level-set based topology optimization considering milling directions via fictitious physical model

Mechanical Engineering Journal, 2020
Topology optimization is the most flexible structural optimization method that allows the topological modification as well as the shape changes. Topology optimization techniques have recently been utilized in engineering applications regarding multi ...
Doe YOUNG HUR, Yuki SATO, Takayuki YAMADA, Kazuhiro IZUI, Shinji NISHIWAKI   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Extension des méthodes DFM pour l'industrialisation de produits microélectroniques [PDF]

, 2011
Résumé - L'industrie des semi-conducteurs (SMI) est caractérisée par de rapides évolutions sur une courte période de temps. Pour maîtriser les temps de développement (Time to Market) et les montées en cadence (Time-to-Volume), le DFM (Design for ...
SIADAT, Ali, TOLLENAERE, Michel, SHAHZAD, Muhammad Kashif, HUBAC, Stéphane   +3 more
core  

Design and evaluation of feedback system in design for manufacturability [PDF]

, 2015
The research study evaluated the effect of different manufacturability feedback modalities on design engineers’ ability to improve the manufacturability of their designs. A manufacturability feedback tool called the Three Dimensional Integrated Feedback (
Barnawal, Prashant
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Automated Manufacturability Analysis: A Survey [PDF]

, 1995
In the marketplace of the 21st century, there is no place for traditional ``over-the-wall'' communications between design and manufacturing. In order to ``design it right the very first time,'' designers must ensure that their products are both ...
Gupta, Satyandra K., William C. Regli, Satyandra K. Gupta, Dana S. Nau, Regli, W.C., Das, Diganta, Diganta Das, Nau, Dana S.   +7 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Applying artificial intelligence to accelerate and de-risk antibody discovery

Frontiers in Drug Discovery
As in all sectors of science and industry, artificial intelligence (AI) is meant to have a high impact in the discovery of antibodies in the coming years.
Astrid Musnier, Christophe Dumet, Saheli Mitra, Adrien Verdier, Raouf Keskes, Augustin Chassine, Yann Jullian, Mélanie Cortes, Yannick Corde, Zakaria Omahdi, Vincent Puard, Thomas Bourquard, Anne Poupon, Anne Poupon   +13 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source