Results 81 to 90 of about 19,710 (294)

A Targeted Integration-Based CHO Cell Platform for Simultaneous Antibody Display and Secretion

Antibodies
Objective: We developed a targeted integration-based CHO cell platform for simultaneous antibody display and secretion, enabling a streamlined transition from antibody library screening to production without requiring the re-cloning of antibody genes ...
Jessica P. Z. Ng, Mariati Mariati, Jiawu Bi, Matthew Wook Chang, Yuansheng Yang   +4 more
doaj   +1 more source

Additive manufacturing: the future of manufacturing

Materiali in tehnologije, 2017
Abstract: Additive manufacturing process is an advanced manufacturing method that is used to fabricate prototypes, tooling, as well as functional product. Additive manufacturing process can produce complex part as a single unit object that was not possible with the traditional manufacturing methods.
Adekanye, Adefemi, Mahamood, Rasheedat M., Akinlabi, Esther Titilayo, Owolabi, Moses G.   +3 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Optimizing Beam Stiffness and Beam Modal Response with Variable Spacing and Extrusion (VaSE)

Designs
This paper presents a novel algorithm, Variable Spacing and Extrusion (VaSE), designed to optimize the infill pattern of material extrusion (ME) 3D-printed parts for specified mechanical performance while ensuring manufacturability. The algorithm adjusts
Patrick N. Murphy, Richard A. Vittum, Bashir Khoda   +2 more
doaj   +1 more source

Economics in Manufactures [PDF]

Science, 1899
n ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Design for manufacturability with advanced lithography

, 2016
This book introduces readers to the most advanced research results on Design for Manufacturability (DFM) with multiple patterning lithography (MPL) and electron beam lithography (EBL).
Yu, Bei, Pan, David Z
core   +1 more source

Adaptive Variable Design Algorithm for Improving Topology Optimization in Additive Manufacturing Guided Design

Inventions
CAD-CAE software companies have introduced numerous tools aimed at facilitating topology optimization through Finite Element Simulation, thereby enhancing accessibility for designers via user-friendly interfaces.
Abraham Vadillo Morillas, Jesús Meneses Alonso, Alejandro Bustos Caballero, Cristina Castejón Sisamón, Alessandro Ceruti   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Resources in manufacturing

, 2019
Standards and ontologies for manufacturing differently understand resources. Because of this heterogeneity, misunderstandings arise concerning the basic features that characterise them. The purpose of the paper is to shed some light on the ontology of resources to strive the development of computational models for manufacturing.
Sanfilippo Emilio M, Terkaj Walter, Borgo Stefano   +2 more
openaire   +4 more sources