Results 101 to 110 of about 2,561,996 (344)
GLHAD: A Group Lasso-Based Hybrid Attack Detection and Localization Framework for Multistage Manufacturing Systems [PDF]
, 2023 Ahmad Kokhahi, Dan Li
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Наука КрасноярьяThe article presents an analysis and assessment of the Republic of Tyva as one of the largest producers of meat and meat products in Russia. The Republic has regional characteristics that are associated with climatic, environmental features, as well as ...
Maria M. Chernyakova, Mikhail V. Tabaev
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review
PharmaceuticsDry powder inhalers (DPI’s) are becoming increasingly popular due to growing interest in pulmonary drug delivery and their performance is the net result of a series of processes carried out during the formulation development and manufacturing process ...
Tanu Mehta +4 more
doaj +1 more source
Effective Mechanical Properties of AlSi7Mg Additively Manufactured Cubic Lattice Structures
, 2021 Sara Mantovani +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Production and Manufacturing Research: An Open Access JournalManufacturing companies operate in a complex environment and need efficient manufacturing processes to remain competitive. Therefore, evaluation methods are essential for decision makers when selecting manufacturing innovation projects (MIPs).
Quirin Gärtner +3 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source