Results 121 to 130 of about 495,254 (268)

Tiered manufacturing of pharmaceuticals as a commercial determinant of health: Implications for medicine quality and equity. [PDF]

PLOS Glob Public Health
Rusatira JC, Pal E, Uwimana JB, Khan A, Novoa MD, Suryanarayanan S, Schoukroun-Barnes L, Peterson C, Michtalik H, Kapeta AB, Mukanga D, Ahmed S, Lumpkin M, Preston C.   +13 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The impact of intelligent manufacturing strategy on enterprise labor productivity: evidence from a quasi-natural experiment in China. [PDF]

Front Artif Intell
Chen M, Xu H, Tian F, Ji L.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Large-scale manufacturing of precisely patterned flexible soft tissue implants with high porosity. [PDF]

Biofabrication
Shabazz A, Christensen AP, Garvey D, Pallotta M, Vakili S, Farias S, Fisher JP.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Application-matched point-of-care 3D printing of functionalized polyetheretherketone (PEEK) composites for patient-specific craniomaxillofacial implants. [PDF]

3D Print Med
Oteiza JZ, Krieger Y, Seiler D, Thieringer FM, Sharma N.   +4 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

3D-Printed Plantar Orthoses and the Conditional Viability of Recycled PLA. [PDF]

Biomimetics (Basel)
Arce E, Losada-Pérez S, Devesa-Rey R, Álvarez-Feijoo MÁ, Agregán P, Leirós-Rodríguez R.   +5 more
europepmc   +1 more source