Results 121 to 130 of about 3,117,564 (363)

Application of Bayesian Optimization in Gripper Design for Effective Grasping

IEEE Access
Despite many recent technological advancements, grasping remains a challenging open problem in robotic manipulation. In contrast with most research which focuses equipping grippers with varying degree of intelligence, we approach grasping from a gripper ...
Marco Todescato, Dominik T. Matt, Andrea Giusti   +2 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Jeffrey Manufacturing Company 75th Anniversary Open House

, 1952
A banner across East First Avenue welcomes guests to the 75th Anniversary Open House at the Jeffrey Manufacturing Company in Columbus, Ohio. The Jeffrey headquarters building and factory buildings can be seen in the background, and a man with his hands ...
The Jeffrey Manufacturing Company (Photographer)
core  

CURRENT STATE AND FACTORS DETERMINING THE COMPETITIVENESS OF MEAT ENTERPRISES INDUSTRY OF THE REPUBLIC OF TUVA

Наука Красноярья
The article presents an analysis and assessment of the Republic of Tyva as one of the largest producers of meat and meat products in Russia. The Republic has regional characteristics that are associated with climatic, environmental features, as well as ...
Maria M. Chernyakova, Mikhail V. Tabaev
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review

Pharmaceutics
Dry powder inhalers (DPI’s) are becoming increasingly popular due to growing interest in pulmonary drug delivery and their performance is the net result of a series of processes carried out during the formulation development and manufacturing process ...
Tanu Mehta, Saeed Najafian, Komalkumar Patel, Justin Lacombe, Bodhisattwa Chaudhuri   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Jeffrey Manufacturing Company Forge Shop

, 1890
Forge shop of the Jeffrey Manufacturing Company, Columbus, Ohio, ca. 1890, where forged metal needed for building Jeffrey products was created . On the dirt floor are flat and round chains forged in the shop. A lack of electrical overhead lighting and an
The Jeffrey Manufacturing Company (Photographer)
core  

Combining the analytical hierarchy process, fuzzy expert systems, and the exponential risk priority number for the holistic evaluation of innovation projects in manufacturing

Production and Manufacturing Research: An Open Access Journal
Manufacturing companies operate in a complex environment and need efficient manufacturing processes to remain competitive. Therefore, evaluation methods are essential for decision makers when selecting manufacturing innovation projects (MIPs).
Quirin Gärtner, Alessandro Bianchi, Harsh Mulrav, Gunther Reinhart   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source