Results 111 to 120 of about 3,117,564 (363)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Jeffrey Manufacturing Company Shop View

open access: yes, 1890
Exterior view of the Jeffrey Manufacturing Company factories, Columbus, Ohio, ca. 1890. The particular use of each building is unknown.
The Jeffrey Manufacturing Company (Photographer)
core  

Human Factors and Ergonomics in Industry 5.0—A Systematic Literature Review

open access: yesApplied Sciences
Human-centricity, sustainability, and resilience are the core pillars of the Industry 5.0 concept. The human-centric perspective emphasizes the development of socio-technical systems designed to enhance human health, safety, and well-being while ...
Maja Trstenjak   +3 more
doaj   +1 more source

Additive manufacturing: scientific and technological challenges, market uptake and opportunities

open access: yes, 2017
Additive manufacturing (AM) is fundamentally different from traditional formative or subtractive manufacturing in that it is the closest to the ‘bottom up’ manufacturing where a structure can be built into its designed shape using a ‘layer-by-layer ...
S. Tofail   +5 more
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Jeffrey Manufacturing Company mortar mixer photograph

open access: yes, 1899
This photograph depicts a one-horsepower mortar mixer used during the construction of a factory building at the Jeffrey Manufacturing Company in Columbus, Ohio. Steel paddles on a long shaft in the trough were turned by the horse to mix the cement mortar.
The Jeffrey Manufacturing Company (Photographer)
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Jeffrey Manufacturing Company 200-Ton Testing Plant

open access: yes, 1895
Jeffrey Manufacturing Company of Columbus, Ohio, built this testing plant to stress test its industrial chain and other machine ...
The Jeffrey Manufacturing Company (Photographer)
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Jeffrey Manufacturing Company Foundry Under Construction

open access: yes, 1899
This picture, taken July 20, 1899, shows the erection of a new foundry for the Jeffrey Manufacturing Company of Columbus ...
The Jeffrey Manufacturing Company (Photographer)
core  

Home - About - Disclaimer - Privacy