Results 111 to 120 of about 1,654,996 (316)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Application of Bayesian Optimization in Gripper Design for Effective Grasping
IEEE AccessDespite many recent technological advancements, grasping remains a challenging open problem in robotic manipulation. In contrast with most research which focuses equipping grippers with varying degree of intelligence, we approach grasping from a gripper ...
Marco Todescato +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Наука КрасноярьяThe article presents an analysis and assessment of the Republic of Tyva as one of the largest producers of meat and meat products in Russia. The Republic has regional characteristics that are associated with climatic, environmental features, as well as ...
Maria M. Chernyakova, Mikhail V. Tabaev
doaj +1 more source
Jeffrey Manufacturing Company 200-Ton Testing Plant
, 1895 Jeffrey Manufacturing Company of Columbus, Ohio, built this testing plant to stress test its industrial chain and other machine ...
The Jeffrey Manufacturing Company (Photographer)
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review
PharmaceuticsDry powder inhalers (DPI’s) are becoming increasingly popular due to growing interest in pulmonary drug delivery and their performance is the net result of a series of processes carried out during the formulation development and manufacturing process ...
Tanu Mehta +4 more
doaj +1 more source
Jeffrey Manufacturing Company 75th Anniversary Open House
, 1952 A banner across East First Avenue welcomes guests to the 75th Anniversary Open House at the Jeffrey Manufacturing Company in Columbus, Ohio. The Jeffrey headquarters building and factory buildings can be seen in the background, and a man with his hands ...
The Jeffrey Manufacturing Company (Photographer)
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Production and Manufacturing Research: An Open Access JournalManufacturing companies operate in a complex environment and need efficient manufacturing processes to remain competitive. Therefore, evaluation methods are essential for decision makers when selecting manufacturing innovation projects (MIPs).
Quirin Gärtner +3 more
doaj +1 more source