Results 141 to 150 of about 1,654,996 (316)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Jeffrey Manufacturing Company Chain Shop
, 1890 This is a view of the chain shop of the Jeffrey Manufacturing Company of Columbus, Ohio, ca. 1895. All of the floor machines were powered from an overhead system of drive shafts, pulleys and belts.
The Jeffrey Manufacturing Company (Photographer)
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Jeffrey Manufacturing Company "Saddleback" Yard Locomotive
, 1910 The Jeffrey Manufacturing Company used small steam-powered locomotives to move rail cars loaded with materials or products in the yard and from factory building to building. A crew of five full time employees were needed to operate and maintain the 0-4-0
The Jeffrey Manufacturing Company (Photographer)
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Jeffrey Manufacturing Company Main Shop Building
, 1890 This is a photograph of the main shop building of the Jeffrey Manufacturing Company, Columbus, Ohio, ca. 1895. This image only depicts half of the shop floor.
The Jeffrey Manufacturing Company (Photographer)
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Jeffrey Manufacturing Company main factory building
, 1952 In 1952, the Jeffrey Manufacturing Company of Columbus, Ohio, celebrated its 75th Anniversary with an open house held at its factory and grounds at North Fourth Street and East First Avenue.
The Jeffrey Manufacturing Company (Photographer)
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Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
[Clipping: Reynolds Aluminum Manufacturing]
Light blue pamphlet advertising the forty manufacturing locations of Reynolds Aluminum throughout the United States.
Reynolds Aluminum Manufacturing
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