Results 151 to 160 of about 3,117,564 (363)

Jeffrey Manufacturing Company molding machine hoppers photograph

open access: yes, 1955
This line of molding machine hoppers operating at Forest City Foundries in Cleveland, Ohio, in 1955, was produced by the Jeffrey Manufacturing Company of Columbus, Ohio.
The Jeffrey Manufacturing Company (Photographer)
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MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Jeffrey Manufacturing Company "Saddleback" Yard Locomotive

open access: yes, 1910
The Jeffrey Manufacturing Company used small steam-powered locomotives to move rail cars loaded with materials or products in the yard and from factory building to building. A crew of five full time employees were needed to operate and maintain the 0-4-0
The Jeffrey Manufacturing Company (Photographer)
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Jeffrey Manufacturing Company Warehouse

open access: yes, 1923
Exterior of a Jeffrey Manufacturing Company warehouse located in Terre Haute, Indiana, 1923.
Fred A. Behmer for the Jeffrey Manufacturing Company (Photographer)
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Jeffrey Manufacturing Company Exhibit

open access: yes, 1927
Display of products made by the Jeffrey Manufacturing Company of Columbus, Ohio at the American Mining Congress held in Cincinnati, Ohio, 1927. The two boxes seen on the floor are electric locomotive speed controllers.
Fred A. Behmer for the Jeffrey Manufacturing Company (Photographer)
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Jeffrey Manufacturing Company Main Shop Building

open access: yes, 1890
This is a photograph of the main shop building of the Jeffrey Manufacturing Company, Columbus, Ohio, ca. 1895. This image only depicts half of the shop floor.
The Jeffrey Manufacturing Company (Photographer)
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