Results 81 to 90 of about 469,015 (246)

Application of Bayesian Optimization in Gripper Design for Effective Grasping

IEEE Access
Despite many recent technological advancements, grasping remains a challenging open problem in robotic manipulation. In contrast with most research which focuses equipping grippers with varying degree of intelligence, we approach grasping from a gripper ...
Marco Todescato, Dominik T. Matt, Andrea Giusti   +2 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

CURRENT STATE AND FACTORS DETERMINING THE COMPETITIVENESS OF MEAT ENTERPRISES INDUSTRY OF THE REPUBLIC OF TUVA

Наука Красноярья
The article presents an analysis and assessment of the Republic of Tyva as one of the largest producers of meat and meat products in Russia. The Republic has regional characteristics that are associated with climatic, environmental features, as well as ...
Maria M. Chernyakova, Mikhail V. Tabaev
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review

Pharmaceutics
Dry powder inhalers (DPI’s) are becoming increasingly popular due to growing interest in pulmonary drug delivery and their performance is the net result of a series of processes carried out during the formulation development and manufacturing process ...
Tanu Mehta, Saeed Najafian, Komalkumar Patel, Justin Lacombe, Bodhisattwa Chaudhuri   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Combining the analytical hierarchy process, fuzzy expert systems, and the exponential risk priority number for the holistic evaluation of innovation projects in manufacturing

Production and Manufacturing Research: An Open Access Journal
Manufacturing companies operate in a complex environment and need efficient manufacturing processes to remain competitive. Therefore, evaluation methods are essential for decision makers when selecting manufacturing innovation projects (MIPs).
Quirin Gärtner, Alessandro Bianchi, Harsh Mulrav, Gunther Reinhart   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Relationship between Respondent Characteristics and Noise Intensity with Increased Blood Pressure in Production Unit Workers of PT Japfa Comfeed Indonesia, Tbk. Plant Margomulyo

Jurnal Ilmiah Kesehatan
The most common physical risk at work is noise, which may cause several health issues. These include diseases of the auditory system and non-auditory impacts including poor communication, tension, anxiety, high blood pressure, and decreased ...
Sofia Sofia, Endang Dwiyanti, Nisrina Oksigendaru Dicha, Andrea Thrisiawan Pradhana   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source