Results 91 to 100 of about 1,340,318 (304)

Research on the new process of separating hollow work-piece by eccentric torsion cutting for stamping [PDF]

FME Transactions
This work aims to conduct theoretical and experimental studies on the energy and force parameters of the separation process, as well as the geometric accuracy of the separated tubular workpiece using the "eccentric twisting" method.
Karnaukh Sergii G., Markov Oleg E., Lysenko Anton A.   +2 more
doaj   +1 more source

Teaching flexible manufacturing system in university education for future engineers [PDF]

, 2007
Flexible Manufacturing System (FMS) typically possesses multiple automated stations and is capable of variable routing among stations. Human resource development, equipment operator skills, manufacture of processing tools, products, processes ...
Hilmi, Ahmad Humaizi, Rajamony, Bhuvenesh   +1 more
core  

Scoping Review of the development of artificial eyes throughout the years [PDF]

, 2016
Losing an eye following trauma can lead to profound psychosocial difficulties making it imperative for the wearer to be fitted with an aesthetically pleasing custom-made artificial eye.
Chinnery, H., Dyer, B., Noroozi, S., Thompson, S. B. N.   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Economics of polysilicon process: A view from Japan [PDF]

The production process of solar grade silicon (SOG-Si) through trichlorosilane (TCS) was researched in a program sponsored by New Energy Development Organization (NEDO). The NEDO process consists of the following two steps: TCS production from by-product
Shimizu, Y.
core   +1 more source

Pictorial display of materials and processes aids in fabricating complex assemblies [PDF]

, 1971
Method uses assembly consisting of single pictorial display showing cutaway view of assembly, subassemblies identified by name and materials, and processes identified by both specification and commercial design.
Ehret, R. M., Fawkes, G. J.
core   +1 more source

Material Strength in Polymer Shape Deposition Manufacturing [PDF]

, 1998
Shape Deposition Manufacturing (SDM) is a layered manufacturing process involving an iterative combination of material addition and material removal. Polymer SDM processes have used castable thermoset resins to build a variety of parts. The strength of
Kietzman, J. W., Prinz, F. B.
core   +2 more sources