Results 91 to 100 of about 236,964 (263)

A robust optimal scheduling system based on multi-performance driving for complex manufacturing systems. [PDF]

Sci Rep, 2023
Yu Q, Zhang Y, Zhao H, Yu T, Li L.
europepmc   +1 more source

Security Framework for Network-Based Manufacturing Systems with Personalized Customization: An Industry 4.0 Approach. [PDF]

Sensors (Basel), 2023
Hammad M, Jillani RM, Ullah S, Ullah S, Namoun A, Tufail A, Kim KH, Shah H.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Production‐Logistics Synchronisation Mechanism and Method of Cellular Assembly Systems Based on Digital‐Twin and Out‐of‐Order Execution

IET Collaborative Intelligent Manufacturing
In the realm of customised production modes, where dynamic disturbances are frequent, synchronised operations between production and logistics in cellular assembly systems play a pivotal role in swiftly responding to rapidly evolving personalised demands.
Weijie Zeng, Mingxing Li, Binyang Liu, Ting Qu, George Q. Huang   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Elastomer-Based Visuotactile Sensor for Normality of Robotic Manufacturing Systems. [PDF]

Polymers (Basel), 2022
Zaid IM, Halwani M, Ayyad A, Imam A, Almaskari F, Hassanin H, Zweiri Y.   +6 more
europepmc   +1 more source

Manufacturers' implementation of circular economy practices and renewable energy sources in Saudi Arabia's industrial plants

Sustainable Environment
A dearth of research has addressed the growing integration of circular economy (CE) practices and renewable energy (RE) sources in industrial settings, motivating the commencement of the present study.
Mohammed Farhan Alqahtani, Mohamed Afy-Shararah, Konstantinos Salonitis   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Smart manufacturing inspired approach to research, development, and scale-up of electrified chemical manufacturing systems. [PDF]

iScience, 2023
Richard D, Jang J, Çıtmacı B, Luo J, Canuso V, Korambath P, Morales-Leslie O, Davis JF, Malkani H, Christofides PD, Morales-Guio CG.   +10 more
europepmc   +1 more source