Results 81 to 90 of about 18,441 (213)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
UML-oriented Risk Analysis in Manufacturing Systems
Acta Polytechnica, 2010 Whenever we want to avoid failures or hazardous events in today’s complex technological systems, it is advisable to carry out appropriate risk management. One of the most important aspects of risk management is the risk analysis process.
J. Jirsa, J. Žáček
doaj
EngOccupational safety is increasingly addressed through engineering-based, proactive risk management approaches that emphasize early identification and mitigation of hazards within industrial systems.
Mirel Glevitzky +4 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Modeling Production of Audio Systems Using Simulation
International Journal of Management Studies, 2004 The manufacturing sector has become an essential sector in Malaysia. This sector needs to be efficient and sound in facing great competition. Reducing costs will ensure that manufacturing companies remain competitive in the market.
Zurina Hanafi, Razman Mat Tahar
doaj
Anbar Journal of Engineering SciencesThis study introduces a cloud-edge smart manufacturing architecture for task scheduling using a hybrid NSGA-II and Improved Monarch Butterfly Optimization approach.
Ahmed Ahmed +3 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
IET Collaborative Intelligent ManufacturingIn human‐centric smart manufacturing (HCSM), the robot's dynamic obstacle avoidance function is crucial to ensuring human safety. Unlike the static obstacle avoidance of manipulators or mobile robots, the dynamic obstacle avoidance in mobile manipulators
Yong Tao +6 more
doaj +1 more source