Results 71 to 80 of about 257,611 (263)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Workplace Safety in Industry 4.0 and Beyond: A Case Study on Risk Reduction Through Smart Manufacturing Systems in the Automotive Sector

Safety
An important step toward automation and digitization in Industry 4.0 is the automobile sector’s use of smart manufacturing integrated systems (SMISs).
Alin Nioata, Alin Țăpirdea, Oana Roxana Chivu, Anamaria Feier, Ioana Catalina Enache, Marilena Gheorghe, Claudia Borda   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Welding defect detection with image processing on a custom small dataset: A comparative study

IET Collaborative Intelligent Manufacturing
This work focuses on detecting defects in welding seams using the most advanced You Only Look Once (YOLO) algorithms and transfer learning. To this end, the authors prepared a small dataset of images using manual welding and compared the performance of ...
József Szőlősi, Béla J. Szekeres, Péter Magyar, Bán Adrián, Gábor Farkas, Mátyás Andó   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Laminator trust in human–robot collaboration for manufacturing fibre‐reinforced composites

IET Collaborative Intelligent Manufacturing
Fibre‐reinforced composites manufacturing is a large and growing industry, with much of the work carried out manually by skilled human laminators. The physical nature of the work can be significantly deleterious to these workers' health, while growing ...
Laura Rhian Pickard, Michael Elkington
doaj   +1 more source

Optimal Operation of a Tablet Pressing Machine Using Deep-Neural-Network-Embedded Mixed-Integer Linear Programming

Inventions
This paper presents a deep neural network (DNN)-embedded mixed-integer linear programming (MILP) model for fault prediction and production optimization in tablet pressing machines.
Jialong Li, Lan Wu, Yuang Qin, Haojun Zhi   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Dynamic Classifier Auditing by Unsupervised Anomaly Detection Methods: An Application in Packaging Industry Predictive Maintenance

Applied Sciences
Predictive maintenance in manufacturing industry applications is a challenging research field. Packaging machines are widely used in a large number of logistic companies’ warehouses and must be working uninterruptedly.
Fernando Mateo, Joan Vila-Francés, Emilio Soria-Olivas, Marcelino Martínez-Sober, Juan Gómez-Sanchis, Antonio José Serrano-López   +5 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source