Results 101 to 110 of about 1,574,435 (263)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Organizational alternatives for flexible manufacturing systems [PDF]
There is an increasing importance of different productive architectures related to worker involvement in the decision making, where is given due attention to the intuitive capabilities and the human knowledge in the optimization and flexibilization of ...
Moniz, António
core +1 more source
, 2012 This article introduces a formal model to specify, model and validate hierarchical complex systems described at different levels of analysis. It relies on concepts that have been developed in the multi-agent-based simulation (MABS) literature: level ...
Dupont, Daniel +3 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
UML-oriented Risk Analysis in Manufacturing Systems
Acta Polytechnica, 2010 Whenever we want to avoid failures or hazardous events in today’s complex technological systems, it is advisable to carry out appropriate risk management. One of the most important aspects of risk management is the risk analysis process.
J. Jirsa, J. Žáček
doaj
Anbar Journal of Engineering SciencesThis study introduces a cloud-edge smart manufacturing architecture for task scheduling using a hybrid NSGA-II and Improved Monarch Butterfly Optimization approach.
Ahmed Ahmed +3 more
doaj +1 more source
Production planning systems for cellular manufacturing [PDF]
New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development.
Riezebos, J.
core +1 more source
Technology assessment of advanced automation for space missions [PDF]
, 1982 Six general classes of technology requirements derived during the mission definition phase of the study were identified as having maximum importance and urgency, including autonomous world model based information systems, learning and hypothesis ...
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source