Results 71 to 80 of about 1,574,435 (263)

Computational tasks in robotics and factory automation [PDF]

, 1988
The design of Manufacturing Planning and Control Systems (MPCSs) — systems that negotiate with Customers and Suppliers to exchange products in return for money in order to generate profit, is discussed.\ud \ud The computational task of MPCS components ...
Biemans, Frank P., Vissers, Chris A.
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Knowledge Driven Machine Learning Towards Interpretable Intelligent Prognostics and Health Management: Review and Case Study

Chinese Journal of Mechanical Engineering
Despite significant progress in the Prognostics and Health Management (PHM) domain using pattern learning systems from data, machine learning (ML) still faces challenges related to limited generalization and weak interpretability. A promising approach to
Ruqiang Yan, Zheng Zhou, Zuogang Shang, Zhiying Wang, Chenye Hu, Yasong Li, Yuangui Yang, Xuefeng Chen, Robert X. Gao   +8 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Advanced Manufacturing Technologies: Development and Prospect

Applied Sciences
The main aim of this Special Issue was to present the current state of the research on the subjects of theory, modeling, monitoring, and control of the operation of technology systems and processes, along with research and diagnostics of manufacturing ...
Tibor Krenicky
doaj   +1 more source

The new challenges of the manufacturing industry applying the norm ISO 45001:2018 [PDF]

, 2019
The present work reflects the impact that the manufacturing industries must solve in the application of the ISO 45001: 2018 Standard on Occupational Health and Safety Management Systems. In such, a globalized market where human and material assets must
Cano-Iglesias, Maria Jose, Cañero, Juan Miguel, Solano-Martos, Jose Francisco   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Driving sustainability: assessing KPI effectiveness in the Saudi chemical industry

Discover Sustainability
This study explores the relationship between Key Performance Indicators (KPIs) and environmental performance improvement within the Saudi chemical industry.
Alaa Alfarsi, Ziyad Sherif, Sandeep Jagtap, Sumit Gupta, Konstantinos Salonitis   +4 more
doaj   +1 more source

Design & development of a simulation model to analyse scheduling rules in an FMS in a virtual manufacturing environment : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Manufacturing and Industrial Technology at Massey University [PDF]

, 1997
Due to the rapid changes in the needs of the customer for new products, the future manufacturing systems must cope with these changes. Hence, the need for the manufacturing systems to support these changes in the products with shorter lead times within a
Talla, Ajay Bhushan
core  

A multi-sensor based online tool condition monitoring system for milling process [PDF]

, 2018
Tool condition monitoring has been considered as one of the key enabling technologies for manufacturing optimization. Due to the high cost and limited system openness, the relevant developed systems have not been widely adopted by industries, especially ...
Li, Weidong, Lu, Xin, Wang, Sheng, Wang, Wei, Zhang, Xiaoyang   +4 more
core   +1 more source