Results 61 to 70 of about 6,938,572 (266)
Гуманитарный вектор, 2019 The article presents a review of the monograph “Buddhism in Mongolia: History, Clergy, Monasteries” written by a famous Russian scholar Tsymzhit Purbuevna Vanchikova.
Bazarov A.A.
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Heritage SciencePresence of copying pencils in heritage objects poses a significant challenge for conservators due to their proneness to fading, sensitivity to solvents and difficulties in differentiation from regular graphite pencils.
Małgorzata Grzelec
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The oldest collage art in the Quran Museum of Astan Quds Razavi from the Seljuk Era [PDF]
کتابداری و اطلاعرسانیObjective: The collage art is one of the branches of book layout in Islamic civilization entered Iran from the East and during the Timurid period; however, this research revealed that the history of the art of cutting dates back to the Seljuk period and ...
Vahid Tavassoli
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Is the Chuu Silk Manuscript a Chuu manuscript?
, 2009 The Chuu Silk Manuscript, known to the scholarly community since the 1950s, was until the manuscript discoveries of the past three decades one of the few extant exemplars of pre-Hann Chinese manuscripts. Because it was found in the area of the ancient state of Chuu and is in its physical appearance and contents very distinctive, incorporating both text
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
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