Results 151 to 160 of about 12,863,015 (313)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Parental perceptions of children's physical activity participation: An exploration of satisfaction, school-based engagement, barriers to participation and preferred strategies for improvement. [PDF]

PLoS One
Ojukwu CP, Chukwunonyelum Judith O, Onyekwelu AI, Eleje C, Ekowa JL, Fatai KE.   +5 more
europepmc   +1 more source

Sion/Sitten, Médiathèque Valais, S 102 : Composite manuscript with legal treatises (Johannes de Blanosco, Aegidius de Fuscarariis, Tancredus Bononiensis, ...)

This manuscript from the library of Walter Supersaxo (ca. 1402-1482), Bishop of Sion, and of his son Georg (ca. 1450-1529), with initials in red and blue (some with pen-flourish initials, e.g. on ff. 1r and 113v; two drawings on ff.
Supersaxo, Georg, Blanasco, Johannes de, Tancredus, Bononiensis, Aegidius, de Fuscarariis, Raimundus, de Pennaforti, Supersaxo, Walter   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Successful treatment of rituximab-refractory pemphigus vulgaris with Obinutuzumab. [PDF]

An Bras Dermatol
Saraç MT, Aygün Alizada M, Erol Mart HM, Boyvat A, Şanlı H, Öktem A.   +5 more
europepmc   +1 more source

Cologny, Fondation Martin Bodmer, Cod. Bodmer 709 : Collection of texts related to the worship of Viṣṇu

This is a composite manuscript, written in Devanāgarī script bearing the influence of the Kashmiri style, bringing together a number of ritual texts dealing with the worship of Viṣṇu. 1. (ff.

core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Orbital compartment syndrome following the use of sinonasal oxidized cellulose and gelatin sponge hemostat: report of two cases and literature review. [PDF]

Int J Ophthalmol
Ghahvehchian H, Kashkouli MB, Karimi N, Jamshidian Tehrani M, Aghai G, Manavishad A.   +5 more
europepmc   +1 more source

Hermetschwil, Benediktinerinnenkloster, Cod. chart. 57 : Lives of Fathers

This manuscript contains a collection of classical descriptions of lives of monks in a High Alemannic translation. It was written by Jos of Ulm.
Basilius, Caesariensis, Hieronymus, Sophronius Eusebius   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source