Results 141 to 150 of about 12,863,015 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Until it was acquired by the Braginsky Collection, this little book with the Birkat ha-mason from 1741 had not been known to research. Clearly it had originally been meant for a woman, probably as a wedding present.
Jakob Sofer ben Juda Löb, aus Berlin
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
This manuscript, disbound and surviving only in fragments, was used in 1543 by the printer Heinrich Petri from Basel as model for his edition of the Rabani Mauri Moguntinensis archiepiscopi commentaria in Hieremiam prophetam.
Fäsch, Ruman, Hrabanus, Maurus
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Zürich, Braginsky Collection, B133 : Tefillah le-Moshe (Moses\u27 Prayers; mystical intentions)
The author of the text of this manuscript, Moses ben Jacob Cordovero (1522-1570), was considered one of the leading figures of the kabbalistic movement in the city of Safed (Upper Galilee), which became the new center of the kabbalistic movement after ...
Modena, Leone +1 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Comment on "Risk factors associated with chronic cutaneous graft-versus-host disease following hematopoietic stem cell transplantation: a pediatric cohort" - Reply. [PDF]
An Bras DermatolCarvajal D +6 more
europepmc +1 more source
St. Gallen, Stiftsbibliothek, Cod. Sang. 718 : Guilelmus Horborch: Decisiones novae Rotae
This manuscript, probably written in Italy in the second quarter of the 15th century, contains the canonist Wilhelm Horborch’s († 1384) collection of judicial decisions of the Rota Romana.
Pater Pius Kolb +5 more
core +1 more source