Results 121 to 130 of about 4,025,753 (264)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Psoriasiform adult blaschkitis triggered by adalimumab: a rare paradoxical reaction. [PDF]

An Bras Dermatol
de Almeida HL, Birck MS, Bialecki LMB, Paganelli A, Martini LB, Duquia RP.   +5 more
europepmc   +1 more source

Hermetschwil, Benediktinerinnenkloster, Cod. A 5a 1 : Hortulus animae, Prayer book

As its first, larger part, this book contains a print: Hortulus animae, Lyon: Johannes Clein for Anton Koberger, 1513. Joined to this is a collection of private prayers.
Muheim, Meliora
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spontaneous septic arthritis of the pubic symphysis mimicking acute abdomen: Diagnostic value of MRI. [PDF]

Radiol Case Rep
Boui M, Benomar AH, Zamani O, Edderai M, Toufga Z, Abdellaoui M, Menaoui OE, Farouki AE, Benchebba D, Chafry B, En-Nouali H, Fenni JE, Saouab R.   +12 more
europepmc   +1 more source

St. Gallen, Stiftsbibliothek, Cod. Sang. 556 : Lives of saints Emmeram, Eligius, Quintin, Cassian. Life of Notker. St. Gall school work, Latin and Old High-German. Miscellaneous

A collection of vitae of various saints from around 900, among them the vita of St. St. Gall monk Notker Balbulus from the early 13th century, written by an unknown monk. The manuscript also contains the so-called "St.
Arbeo, Frisingensis, Pater Pius Kolb, Audoenus, Rothomagensis, Arx, Ildefons von, Ruodpertus   +4 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Socioeconomic determinants of leprosy in Brazilian municipalities: an ecological study. [PDF]

An Bras Dermatol
Golineli AOG, Belli MCV, Lourenço GH, Belli O, Miot HA.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Urodynamics assessment in patients with multiple sclerosis. [PDF]

BJUI Compass
Walker NF, Bacon A, Teji M, Solomon E, Sahai A, Stephens R, Okpii E, Dunford C, Wood S, Speck E, Doherty R, Rantell A, Araklitis G, Lilis L, Nitkunan T, Carey M, Biers S, Berry B, Pakzad M, Hashim H.   +19 more
europepmc   +1 more source