Results 111 to 120 of about 21,652,091 (264)

Bern, Burgerbibliothek, Cod. 120.I : Composite manuscript: Ado Viennensis: Chronicon; Aurelius Victor (Pseudo-): Epitome de Caesaribus; Abbo Floriacensis: De gestis Romanorum pontificum, lat.

This composite manuscript contains various texts in chronicle form, some of them rare, regarding worldly and ecclesiastical rulers. It is a heavily edited and corrected manuscript from the Benedictine Abbey of Saint-Mesmin de Micy, which contains ...
Bürger, Ulrike, Abbo, Floriacensis, Aurelius Victor, Sextus, Daniel, Pierre, Ado, Viennensis, Bongars, Jacques, Hrabanus, Maurus, Prudentius Clemens, Aurelius, Busaeus, Johannes, Lindt, Johann, Gravisset, Jakob von, Guilelmus, Peraldus   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Sion/Sitten, Médiathèque Valais, S 102 : Composite manuscript with legal treatises (Johannes de Blanosco, Aegidius de Fuscarariis, Tancredus Bononiensis, ...)

This manuscript from the library of Walter Supersaxo (ca. 1402-1482), Bishop of Sion, and of his son Georg (ca. 1450-1529), with initials in red and blue (some with pen-flourish initials, e.g. on ff. 1r and 113v; two drawings on ff.
Supersaxo, Georg, Blanasco, Johannes de, Tancredus, Bononiensis, Aegidius, de Fuscarariis, Raimundus, de Pennaforti, Supersaxo, Walter   +5 more
core   +1 more source

Stranded in Dongola: MS Vatican City, Bibliotheca Apostolica Vaticana, Vat. et. 44, 71v–76v, a Colophon by Takla ʾAlfā, Reconsidered

Aethiopica
The paper offers a re-edition of a valuable first-hand account concerning sixteenth-century Sudan, recorded in Gǝʿǝz by the Ethiopian monk Takla ʾAlfā during his stay at Dongola in 1596.
Daria Elagina, Dorota Dzierzbicka
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

St. Gallen, Stiftsbibliothek, Cod. Sang. 320 : Composite manuscript with homiletic and historiographic works

Latin composite manuscript from the period between 1150 and 1250, written in Southern Germany, perhaps even in St. Gall. The volume contains (not quite complete) the sermons of Bernard of Clairvaux on the Old Testament Song of Songs (Sermones super ...
Robertus, Remensis, Adamnanus, de Iona, Bernardus, Claraevallensis   +2 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source