Results 121 to 130 of about 55,648,808 (328)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ethiopian manuscripts and Ethiopian manuscript studies: a brief overview and evaluation

Gazette du livre mxe9dixe9val, 2012
Nosnitsin Denis. Ethiopian Manuscripts and Ethiopian Manuscript Studies. A brief Overview and Evaluation. In: Gazette du livre médiéval, n°58. 2012, fasc. 1. pp. 1-16.
Nosnitsin, Denis
openaire   +3 more sources

Scribal networks

Journal of Historical Network Research, 2023
This paper tests the application of network analysis for the visualization and analysis of palaeographical data. In recent years the 12th century scriptoria of the Austrian Cistercian monasteries of Heiligenkreuz, Zwettl and Baumgartenberg have been ...
Katharina Kaska
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Statistical Analysis of a Posteriori Channel and Noise Distribution Based on HARQ Feedback

, 2016
In response to a comment on one of our manuscript, this work studies the posterior channel and noise distributions conditioned on the NACKs and ACKs of all previous transmissions in HARQ system with statistical approaches. Our main result is that, unless
Ding, Zhi, Mittelmann, Hans, Wu, Wenhao
core  

Introduction: Manuscript Albums as Touchstones for Manuscript Studies

, 2023
Janine Droese, Janina Karolewski
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Phytolith assemblages from palm leaves and palm-leaf manuscripts: what is the difference and what it could mean?

Frontiers in Plant Science
We studied freshly collected, dried and herbarized leaf fragments of two palms, namely Borassus flabellifer L. and Corypha umbraculifera L., most commonly used for palm-leaf manuscript (PLM) production in South (S) and Southeast Asia (SE) in order to ...
Anastasia Poliakova, Anastasia Poliakova, Anastasia Poliakova, Giovanni Ciotti, Giovanni Ciotti, Giovanni Ciotti, Agnieszka Helman-Wazny, Agnieszka Helman-Wazny, Agnieszka Helman-Wazny, Agnieszka Helman-Wazny, Jörg Fromm, Jörg Fromm   +11 more
doaj   +1 more source