Results 101 to 110 of about 354,448 (304)
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
WRITING AND LITERARY ACTIVITY IN THE VERNACULAR IN ANGLO-SAXON ENGLAND [PDF]
, 2013 У статті розглянуто процес виникнення і функціонування різних форм текстової фіксації на англійських територіальних діалектах давнього періоду розвитку англійської мови як наслідок розвитку суспільних функцій мови та розширення сфер функціонування її ...
Євченко, В. В.
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Vyatka region annalistic heritage as a source of the regional Orthodox literature repertoire
Библиосфера, 2015 The article examines Vyatka region annalistic heritage regarding chronicles as a source of the Orthodox literature repertoire. It analyzes Vyatka region manuscript tradition.
L. V. Bayova
doaj
Avant Garde in Chinese Art [PDF]
, 2011 The question that I propose to examine here is to what extent or in what sense there has been an avant-garde presence in Chinese art. And in what sense is the avant-garde present in contemporary Chinese art connected to avant-garde in the west.
Carter, Curtis
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Glorification through Fear in \u3cem\u3e2 Enoch\u3c/em\u3e [PDF]
, 2016 This article explores the imagery of fear found in 2 Enoch and its significance for the glorious transformations that Enoch undergoes during his heavenly journey.
Orlov, Andrei
core +1 more source
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source